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Microscopic colitis...
Microscopic colitis patients have increased frequencies of Ki67+proliferating and CD45RO+ active/memory CD8+ and CD4+8+ mucosal T cells
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- Kumawat, Ashok Kumar (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Strid, Hilja (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Elgbratt, Kristina, 1969- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Tysk, Curt (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept. of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Bohr, Johan, 1957- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept. of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden
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- Hultgren Hörnquist, Elisabeth, 1965- (författare)
- Örebro universitet,Institutionen för läkarutbildning
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(creator_code:org_t)
- Oxford, United Kingdom : Oxford University Press, 2013
- 2013
- Engelska.
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Ingår i: Journal of Crohn's & Colitis. - Oxford, United Kingdom : Oxford University Press. - 1873-9946 .- 1876-4479. ; 7:9, s. 694-705
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Collagenous colitis (CC) and lymphocytic colitis (LC) are chronic inflammatory bowel disorders of unknown etiology. This study investigated phenotypic characteristics of the mucosal lymphocytes in CC and LC.Methods: Lamina propria and intraepithelial lymphocytes (LPLs, IELs) isolated from mucosal biopsies from CC (n = 7), LC (n = 6), as well as LC or CC patients in histopathological remission, (LC-HR) (n = 6) and CC-HR (n = 4) and non-inflamed controls (n = 10) were phenotypically characterized by four-color flow cytometry.Results: The proportions of CD8+ IELs were increased in CC and LC (p < 0.01) compared to controls. Increased proportions of CD45RO+CD8+ IELs and LPLs were observed in LC and even more in CC patients (p < 0.01). Both CC (p < 0.05) and LC patients had elevated proportions of CD4+8+ IELs and LPLs compared to controls. The proportions of CD45RO+ cells were increased in CD4+8+ IELs and LPLs (p < 0.05) in CC and LC patients compared to controls. Both CC (p < 0.05) and LC patients had higher proportions of Ki67+CD8+ IELs and LPLs compared to controls.In contrast, decreased proportions of CD4+ LPLs were observed in CC and LC as well as CD4+ IELs in LC compared to controls. Increased proportions of Ki67+CD4+ IELs and LPLs (p < 0.05) were observed in CC and LC patients. CC-HR but not LC-HR patients demonstrated normalized proportions of both IELs and LPLs compared to CC and LC patients respectively.Conclusion: LC and CC patients have differences in mucosal lymphocyte subsets, with increased proportions of Ki67+ and CD45RO+ CD8+ and CD4+8+ mucosal T cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Collagenous colitis
- Lymphocytic colitis
- Flow cytometry
- Lamina propria lymphocytes
- Intraepithelial lymphocytes
- Medicine
- Medicin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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