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Sökning: onr:"swepub:oai:DiVA.org:oru-27789" > Genetic variation i...

  • Shui, Irene M (författare)

Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2011-05-11
  • Wiley-Blackwell,2012
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-27789
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27789URI
  • https://doi.org/10.1002/pros.21423DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:123903483URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:National Institutes of Health CA090598-03  5 T32 CA09001-35  HL-26490  HL-34595  CA-097193  CA-34944  CA-141298  CA-40360
  • BACKGROUND: Common genetic variants in the Toll-like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer.METHODS: In a large nested case-control study of prostate cancer in the Physicians' Health Study (1982-2004), 10 single nucleotide polymorphisms (SNPs) were selected and genotyped to capture common variation within the TLR4 gene as well as 5 kb up and downstream. Unconditional logistic regression was used to assess associations of these SNPs with total prostate cancer incidence, and with prostate cancers defined as advanced stage/lethal (T3/T4, M1/N1(T1-T4), lethal) or high Gleason grade (7 (4 + 3) or greater). Cox-proportional hazards regression was used to assess progression to metastases and death among prostate cancer cases.RESULTS: The study included 1,267 controls and 1,286 incident prostate cancer cases, including 248 advanced stage/lethal and 306 high grade cases. During a median follow-up of 10.6 years, 183 men died of prostate cancer or developed distant metastases. No statistically significant associations between the TLR4 SNPs were found for total prostate cancer incidence, including SNPs for which an association was reported in other published studies. Additionally, there were no significant associations with TLR4 SNPS and the incidence of advanced stage/lethal, or high grade cancers; nor was there evidence among prostate cancer cases for associations of TLR4 SNPs with progression to prostate cancer specific mortality or bony metastases.CONCLUSIONS: Results from this prospective nested case-control study suggest that genetic variation across TLR4 alone is not strongly associated with prostate cancer risk or mortality.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stark, Jennifer R (författare)
  • Penney, Kathryn L (författare)
  • Schumacher, Fredrick R (författare)
  • Epstein, Mara M (författare)
  • Pitt, Michael J (författare)
  • Stampfer, Meir J (författare)
  • Tamimi, Rulla M (författare)
  • Lindstrom, Sara (författare)
  • Sesso, Howard D (författare)
  • Fall, Katja,1971-Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden(Swepub:oru)kafl (författare)
  • Ma, Jing (författare)
  • Kraft, Peter (författare)
  • Giovannucci, Edward (författare)
  • Mucci, Lorelei A (författare)
  • Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Prostate: Wiley-Blackwell72:2, s. 209-2160270-41371097-0045

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