Sökning: onr:"swepub:oai:DiVA.org:oru-27789" >
Genetic variation i...
-
Shui, Irene M
(författare)
Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
-
2011-05-11
-
Wiley-Blackwell,2012
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-27789
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27789URI
-
https://doi.org/10.1002/pros.21423DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:123903483URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agency:National Institutes of Health CA090598-03 5 T32 CA09001-35 HL-26490 HL-34595 CA-097193 CA-34944 CA-141298 CA-40360
-
BACKGROUND: Common genetic variants in the Toll-like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer.METHODS: In a large nested case-control study of prostate cancer in the Physicians' Health Study (1982-2004), 10 single nucleotide polymorphisms (SNPs) were selected and genotyped to capture common variation within the TLR4 gene as well as 5 kb up and downstream. Unconditional logistic regression was used to assess associations of these SNPs with total prostate cancer incidence, and with prostate cancers defined as advanced stage/lethal (T3/T4, M1/N1(T1-T4), lethal) or high Gleason grade (7 (4 + 3) or greater). Cox-proportional hazards regression was used to assess progression to metastases and death among prostate cancer cases.RESULTS: The study included 1,267 controls and 1,286 incident prostate cancer cases, including 248 advanced stage/lethal and 306 high grade cases. During a median follow-up of 10.6 years, 183 men died of prostate cancer or developed distant metastases. No statistically significant associations between the TLR4 SNPs were found for total prostate cancer incidence, including SNPs for which an association was reported in other published studies. Additionally, there were no significant associations with TLR4 SNPS and the incidence of advanced stage/lethal, or high grade cancers; nor was there evidence among prostate cancer cases for associations of TLR4 SNPs with progression to prostate cancer specific mortality or bony metastases.CONCLUSIONS: Results from this prospective nested case-control study suggest that genetic variation across TLR4 alone is not strongly associated with prostate cancer risk or mortality.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Stark, Jennifer R
(författare)
-
Penney, Kathryn L
(författare)
-
Schumacher, Fredrick R
(författare)
-
Epstein, Mara M
(författare)
-
Pitt, Michael J
(författare)
-
Stampfer, Meir J
(författare)
-
Tamimi, Rulla M
(författare)
-
Lindstrom, Sara
(författare)
-
Sesso, Howard D
(författare)
-
Fall, Katja,1971-Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden(Swepub:oru)kafl
(författare)
-
Ma, Jing
(författare)
-
Kraft, Peter
(författare)
-
Giovannucci, Edward
(författare)
-
Mucci, Lorelei A
(författare)
-
Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States: Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:The Prostate: Wiley-Blackwell72:2, s. 209-2160270-41371097-0045
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Shui, Irene M
-
Stark, Jennifer ...
-
Penney, Kathryn ...
-
Schumacher, Fred ...
-
Epstein, Mara M
-
Pitt, Michael J
-
visa fler...
-
Stampfer, Meir J
-
Tamimi, Rulla M
-
Lindstrom, Sara
-
Sesso, Howard D
-
Fall, Katja, 197 ...
-
Ma, Jing
-
Kraft, Peter
-
Giovannucci, Edw ...
-
Mucci, Lorelei A
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
- Artiklar i publikationen
-
The Prostate
- Av lärosätet
-
Örebro universitet
-
Karolinska Institutet