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Immunogenicity and ...
Immunogenicity and reactogenicity of two diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus-Haemophilus influenzae type b vaccines administered at 3, 5 and 11-12 months of age
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- Kilpi, Terhi M. (författare)
- KTL, Natl Publ Hlth Inst, Dept Vaccines, FIN-00300 Helsinki, Finland,Department of Vaccines; National Public Health Institute (KTL); Helsinki, Finland
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- Silfverdal, Sven Arne (författare)
- Umeå universitet,Örebro universitet,Hälsoakademin,Pediatrik,University of Örebro
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- Nilsson, Lennart (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Allergicentrum,Hälsouniversitetet,Allergicentrum US
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- Syrjanen, Ritva (författare)
- Department of Vaccines; National Public Health Institute (KTL); Helsinki, Finland,San Matteo Hospital
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- Belloni, Cesare (författare)
- San Matteo Hosp, Div Neonatol Neonatal Pathol Intens Care, IRCCS, Pavia, Italy,Division of Neonatology-Neonatal Pathology-Intensive Care; I.R.C.C.S. San Matteo Hospital; Pavia, Italy
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- Desole, Maria (författare)
- AUSL 1, Publ Hlth Serv, Sassari, Italy,Public Health Service; AUSL 1; Sassari, Italy
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- Triban, Chiara (författare)
- GlaxoSmithKline Biologicals; Verona, Italy; Solna, Sweden; Espoo, Finland; Rixensart, Belgium
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- Storsaeter, Jann (författare)
- GlaxoSmithKline Biologicals; Verona, Italy; Solna, Sweden; Espoo, Finland; Rixensart, Belgium
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- Soila, Maaria (författare)
- GlaxoSmithKline Biologicals; Verona, Italy; Solna, Sweden; Espoo, Finland; Rixensart, Belgium
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- Jacquet, Jeanne-Marie (författare)
- GlaxoSmithKline Biologicals; Verona, Italy; Solna, Sweden; Espoo, Finland; Rixensart, Belgium
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(creator_code:org_t)
- 2014-10-27
- 2009
- Engelska.
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Ingår i: HUM VACCINES. - : Informa UK Limited. - 1554-8619 .- 1554-8600. ; 5:1, s. 18-25
- Relaterad länk:
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http://www.landesbio...
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https://urn.kb.se/re...
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https://doi.org/10.4...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The use of combination vaccines in the routine childhood program reduces distress to the recipients and is likely to improve uptake rates and timeliness of vaccination but requires careful evaluation and surveillance. The aim of this study was to evaluate the immunogenicity and reactogenicity of two commercial diphtheria-tetanus-acellular pertussis-hepatitis b-inactivated polio virus-Haemophilus influenzae type b (DTaP-HBV-IPV/Hib) combination vaccines when administered to infants at 3, 5 and 11-12 months of age. A total of 494 infants were randomized to receive three doses of either Infanrix hexa T (GlaxoSmithKline Biologicals; N = 246) or Hexavac (TM) (Sanofi Pasteur MSD; N = 248) in 10 centers in Italy, Finland and Sweden. After the third dose, antibodies to diphtheria, tetanus, polio and Hib were at the protective level in nearly all infants in both groups whereas the proportion of subjects who had achieved the protective concentration of = 10 mIU/ml to hepatitis B surface antigen was 99.1% (95% CI 96.7-99.9) in the Infanrix hexa T group as compared to 94.4% (95% CI 90.4-97.1) in the Hexavac T group. Antibody titers to all three polio antigens were highest in Italy and lowest in Finland. Clinically relevant general reactions (such as fever of >39.5 degrees C) were mostly reported in less than 5% of the vaccinees. Three doses of DTaP-HBV-IPV/Hib combination vaccines produced sufficient immune responses in nearly all vaccinees.
Nyckelord
- combination vaccines
- immunization schedule
- antibodies
- infant
- Medicine
- Medicin
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kilpi, Terhi M.
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Silfverdal, Sven ...
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Nilsson, Lennart
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Syrjanen, Ritva
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Belloni, Cesare
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Desole, Maria
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visa fler...
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Triban, Chiara
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Storsaeter, Jann
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Soila, Maaria
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Jacquet, Jeanne- ...
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- Artiklar i publikationen
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HUM VACCINES
- Av lärosätet
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Örebro universitet
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Umeå universitet
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Linköpings universitet