Sökning: onr:"swepub:oai:DiVA.org:oru-30733" > Reduced T cell rece...
Fältnamn | Indikatorer | Metadata |
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000 | 03948naa a2200409 4500 | |
001 | oai:DiVA.org:oru-30733 | |
003 | SwePub | |
008 | 130906s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-307332 URI |
024 | 7 | a https://doi.org/10.1155/2013/4086382 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kumawat, Ashok Kumar,d 1982-u Örebro universitet,Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)akt |
245 | 1 0 | a Reduced T cell receptor excision circle levels in the colonic mucosa of microscopic colitis patients indicate local proliferation rather than homing of peripheral lymphocytes to the inflamed mucosa |
264 | 1 | a New York, USA :b Hindawi Publishing Corporation,c 2013 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Swedish Society of Medicine (Bengt Ihre Foundation) Örebro University Hospital Research Foundation | |
520 | a Dysregulated T cell responses in the intestine may lead to chronic bowel inflammation such as collagenous colitis (CC) and lymphocytic colitis (LC), together known as microscopic colitis (MC). Having demonstrated increased local T cell responses in the intestinal mucosa of MC patients, we investigated the recent thymic emigrants by measuring T cell receptor excision circle (TREC) levels in the colonic biopsies from CC (n = 8), LC (n = 5), and CC or LC patients in histopathological remission (CC-HR, n = 3) (LC-HR, n = 6), non-inflamed diarrhoea patients (n = 17), and controls (n = 10) by real-time PCR. We observed lower median TREC levels in both CC and LC patients as well as in LC-HR patients compared to controls. In contrast to MC patients, non-inflamed diarrhoea patients presented with enhanced TREC levels compared to controls. None of the recorded differences did, however, reach statistical significance. A trend towards increased relative expression of CD3 was noted in all MC subgroups examined and reached statistical significance in LC patients compared to controls. In conclusion, reduced TRECs level in the colonic mucosa, together with our previously demonstrated enhanced expression of Ki67(+) T cells, suggests local expansion of resident T lymphocytes in the inflamed mucosa of MC patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
653 | a Medicin | |
653 | a Medicine | |
700 | 1 | a Elgbratt, Kristina,d 1969-u Örebro universitet,Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)ket |
700 | 1 | a Tysk, Curt,d 1949-u Örebro universitet,Hälsoakademin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Region Örebro County, Örebro, sweden4 aut0 (Swepub:oru)ctk |
700 | 1 | a Bohr, Johan,d 1957-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län4 aut0 (Swepub:oru)jbr |
700 | 1 | a Hultgren-Hörnquist, Elisabeth,d 1965-u Örebro universitet,Institutionen för läkarutbildning4 aut0 (Swepub:oru)eht |
710 | 2 | a Örebro universitetb Institutionen för hälsovetenskap och medicin4 org |
773 | 0 | t BioMed Research Internationald New York, USA : Hindawi Publishing Corporationx 2314-6133x 2314-6141 |
856 | 4 | u https://doi.org/10.1155/2013/408638y Fulltext |
856 | 4 | u http://downloads.hindawi.com/journals/bmri/2013/408638.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-30733 |
856 | 4 8 | u https://doi.org/10.1155/2013/408638 |
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