Sökning: onr:"swepub:oai:DiVA.org:oru-33753" > Androgen levels dur...
Fältnamn | Indikatorer | Metadata |
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000 | 05124naa a2200481 4500 | |
001 | oai:DiVA.org:oru-33753 | |
003 | SwePub | |
008 | 140214s2014 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-214588 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-337532 URI |
024 | 7 | a https://doi.org/10.3109/13697137.2013.8000392 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2145882 URI |
040 | a (SwePub)orud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Baumgart, Juliane,d 1978-u Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Department of Obstetrics and Gynecology, Örebro University Hospital, Sweden4 aut0 (Swepub:oru)jebt |
245 | 1 0 | a Androgen levels during adjuvant endocrine therapy in postmenopausal breast cancer patients |
264 | c 2013-06-28 | |
264 | 1 | a London, United Kingdom :b Informa Healthcare,c 2014 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Uppsala-Örebro Regional Research Council Swedish Cancer SocietyLions Clubs International Percy Falk Foundation | |
520 | a Objective: To investigate plasma steroid hormone levels in postmenopausal breast cancer patients with and without adjuvant endocrine therapy and in healthy postmenopausal women.Methods: Steroid hormone levels in postmenopausal breast cancer patients treated with aromatase inhibitors (n = 32) were compared with breast cancer patients treated with tamoxifen (n = 34), breast cancer patients without adjuvant endocrine therapy (n = 15), and healthy postmenopausal women (n = 56). Pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, cortisone, dehydroepiandrosterone (DHEA), androstenedione, total testosterone, dihydrotestosterone, estrone and estradiol were measured using liquid chromatography-tandem mass spectrometry. Sex hormone binding globulin was measured by solid-phase chemiluminescent immunometric assays, and the free androgen index was calculated.Results: Aromatase inhibitor users did not differ in dihydrotestosterone, total testosterone, androstenedione, DHEA, or free androgen index levels from healthy controls or untreated breast cancer patients. The highest total testosterone levels were found in tamoxifen-treated women, who had significantly higher plasma concentrations than both women treated with aromatase inhibitors and breast cancer patients without adjuvant treatment. Concentrations of cortisol and cortisone were significantly greater in aromatase inhibitor users as well as tamoxifen users, in comparison with healthy controls and untreated breast cancer patients. Aromatase inhibitor users had lower estrone and estradiol plasma concentrations than all other groups.Conclusion: Adjuvant treatment with aromatase inhibitors or tamoxifen was associated with increased cortisol and cortisone plasma concentrations as well as decreased estradiol concentrations. Androgen levels were elevated in tamoxifen-treated women but not in aromatase inhibitor users. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
653 | a Breast cancer | |
653 | a steroid hormones | |
653 | a LC-MS/MS | |
653 | a aromatase inhibitors | |
653 | a tamoxifen | |
653 | a postmenopausal women | |
700 | 1 | a Nilsson, Kerstin,d 1953-u Örebro universitet,Institutionen för läkarutbildning,Region Örebro län,Department of Obstetrics and Gynecology, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)ktnn |
700 | 1 | a Stavreus Evers, Anneliu Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/olovsson4 aut0 (Swepub:uu)annst384 |
700 | 1 | a Kallak, Theodora Kunovac,d 1985-u Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson4 aut0 (Swepub:uu)theka349 |
700 | 1 | a Kushnir, M. M.u Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA4 aut |
700 | 1 | a Bergquist, Jonasu Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,Department of Pathology, University of Utah School of Medicine, Salt Lake City, USA4 aut0 (Swepub:uu)jbe25356 |
700 | 1 | a Sundström Poromaa, Inger,d 1964-u Uppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa4 aut0 (Swepub:uu)inspo702 |
710 | 2 | a Örebro universitetb Institutionen för hälsovetenskap och medicin4 org |
773 | 0 | t Climactericd London, United Kingdom : Informa Healthcareg 17:1, s. 48-54q 17:1<48-54x 1369-7137x 1473-0804 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33753 |
856 | 4 8 | u https://doi.org/10.3109/13697137.2013.800039 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-214588 |
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