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Increased prevalenc...
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Stenberg, Reidun,1954-Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Dept of Paediatrics, Centre for Rehabilitation Research, Örebro University Hospital,,Örebro University Hospital, Sweden
(författare)
Increased prevalence of antibodies against dietary proteins in children and young adults with cerebral palsy
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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Lippincott, Williams and Wilkins,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-33885
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-33885URI
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https://doi.org/10.1097/MPG.0b013e318272cbf4DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-187166URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-89740URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding agencies are:Research Committee of Orebro County Council Folke Bernadotte Foundation, Stockholm, Sweden
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Funding Agencies|Research Committee of Orebro County Council||Folke Bernadotte Foundation, Stockholm, Sweden||
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OBJECTIVES: Undernourishment is common in children with cerebral palsy (CP), but the reasons are unknown. We previously reported elevated levels of immunoglobulin (Ig) A and IgG antibodies against gliadin (AGA) and tissue transglutaminase (tTG) in 99 children and young adults with CP without characteristic findings of gluten enteropathy in small bowel biopsies. Our aim was to perform a case-control study of IgG antibodies against other dietary antigens, AGA, anti-tTG, and IgE antibodies against wheat and gluten.METHODS: Sera from 99 cases with CP and 99 healthy, age- and sex-matched controls were analysed with fluorescence enzyme-linked immunosorbent assay for detection of IgG antibodies against β-lactoglobulin, casein, egg white, IgG- and IgA-AGA, IgA-anti-tTG, and IgE antibodies against gluten and wheat.RESULTS: Compared with controls, the odds ratio in cases with CP for having elevated levels of IgG antibodies against β-lactoglobulin was 17.0 (95% confidence interval [CI] 2.3-128), against casein 11.0 (95% CI 2.6-46.8), and against egg white 7.0 (95% CI 1.6-30.8). The IgE responses for wheat/gluten were generally low. The tetraplegic and dyskinetic CP subtypes had significantly higher frequencies of elevated levels for all of the tested antibodies except IgG against egg white, and IgA-anti-tTG. A significantly lower weight was seen in cases with CP with positive versus negative serology.CONCLUSIONS: Elevated levels of IgG against dietary antigens were more frequent in the CP group compared with controls, and particularly in the tetraplegic and dyskinetic CP subtypes with the most severe neurologic handicap and undernourishment. Hypothetically, malnourishment may cause increased intestinal permeability and thus immunization against dietary antigens.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Dahle, CharlotteÖstergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin(Swepub:liu)chada46
(författare)
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Magnuson, AndersClinical Epidemiology and Biostatistic Unit, Örebro University Hospital, Örebro, Sweden
(författare)
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Hellberg, Dan,1953-Uppsala universitet,Centrum för klinisk forskning Dalarna,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa,Clin Research Centre, Sweden(Swepub:uu)dahel227
(författare)
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Tysk, CurtÖrebro universitet,Institutionen för hälsovetenskap och medicin,Department of Medicine, Örebro University Hospital, Region Örebro County, Örebro, Sweden,Department of Medicine, Division of Gastroenterology, Örebro University Hospital(Swepub:oru)ctk
(författare)
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Örebro universitetInstitutionen för hälsovetenskap och medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Pediatric Gastroenterology and Nutrition - JPGN: Lippincott, Williams and Wilkins56:2, s. 233-80277-21161536-4801
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