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Livin expression is...
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Ding, Zhen-YuLinköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
(författare)
Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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London, United Kingdom :BioMed Central,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-34273
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-34273URI
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https://doi.org/10.1186/1748-717X-8-281DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-105255URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies:National Major Project of ChinaNational Natural Science Fund of ChinaHealth Research Council in the South-East of Sweden
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Background: This study was aimed to investigate the expression significance of Livin in relation to radiotherapy (RT), clinicopathological and biological factors of rectal cancer patients.Methods: This study included 144 primary rectal cancer patients who participated in a Swedish clinical trial of preoperative radiotherapy. Tissue microarray samples from the excised primary rectal cancers, normal mucosa and lymph node metastases were immunostained with Livin antibody. The proliferation of colon cancer cell lines SW620 and RKO was assayed after Livin knock-down.Results: The expression of Livin was significantly increased from adjacent (P = 0.051) or distant (P = 0.028) normal mucosa to primary tumors. 15.4% (2/13) and 39.7% (52/131) patients with Livin-negative and positive tumors died at 180 months after surgery, and the difference tended to be statistically significant (P = 0.091). In multivariate analyses, the difference achieved statistical significance, independent of TNM stage, local and distant recurrence, grade of differentiation, gender, and age (odds ratio = 5.09, 95% CI: 1.01-25.64, P = 0.048). The in vitro study indicated colon cancer cells with Livin knock-down exhibited decreased proliferation compared with controls after RT.Conclusions: The expression of Livin was was independently related to survival in rectal cancer patients, suggesting Livin as a useful prognostic factor for rectal cancer patients.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zhang, Hong,1957-Örebro universitet,Institutionen för läkarutbildning,University of Örebro, Sweden(Swepub:oru)hzg
(författare)
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Adell, GunnarDepartment of Oncology, Karolinska University Hospital, Stockholm, Sweden
(författare)
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Olsson, BirgitLinköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)birol93
(författare)
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Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45
(författare)
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Linköpings universitetInstitutionen för klinisk och experimentell medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Radiation OncologyLondon, United Kingdom : BioMed Central8:11748-717X
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