Sökning: onr:"swepub:oai:DiVA.org:oru-3496" >
Coeliac disease and...
Coeliac disease and the risk of fractures : a general population-based cohort study
-
- Ludvigsson, Jonas F. (författare)
- Karolinska Institutet,Örebro universitet,Hälsoakademin
-
- Michaëlsson, Karl (författare)
- Uppsala universitet,Ortopedi
-
- Ekbom, A. (författare)
- Karolinska Institutet
-
visa fler...
-
- Montgomery, Scott M. (författare)
- Karolinska Institutet,Örebro universitet,Hälsoakademin,Clinical Research Centre, Örebro University Hospital
-
visa färre...
-
(creator_code:org_t)
- 2006-12-19
- 2007
- Engelska.
-
Ingår i: Alimentary Pharmacology and Therapeutics. - Oxford : Blackwell Scientific. - 0269-2813 .- 1365-2036. ; 25:3, s. 273-285
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Earlier studies have suggested that untreated coeliac disease may be associated with osteoporosis, but results are contradictory for the risk of long-term fractures.Aim: To study the association between coeliac disease and fractures.Methods: We used Cox regresson to examine the future risk of hip fracture and fracture of any type in more than 13 000 individuals with coeliac disease and 65 000 age- and sex-matched reference individuals in a general population-based cohort.Results: During follow-up, 1365 first hip fractures and 4847 fractures of any type occurred. Coeliac disease was positively associated with subsequent hip fracture (hazard ratio = 2.1; 95% CI = 1.8-2.4) (in children: hazard ratio = 2.6; 95% CI = 1.1-6.2) and fractures of any type (hazard ratio = 1.4; 95% CI = 1.3-1.5) (in children: hazard ratio = 1.1; 95% CI = 1.0-1.2). The absolute excess risk of hip fractures in children with coeliac disease was 4/100 000 person-years. Incidence ratios for hip fracture in individuals with CD were around two both prior to diagnosis of coeliac disease and afterwards; this risk increase remained 20 years after diagnosis of coeliac disease.Conclusions: Individuals with coeliac disease, including children with coeliac disease, may be at increased risk of hip fracture and fracture of any type. Coeliac disease may be positively associated with long-term hip fracture risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Aged
- Aged; 80 and over
- Celiac Disease/*complications
- Child
- Child; Preschool
- Cohort Studies
- Female
- Fractures; Bone/*etiology
- Humans
- Infant
- Infant; Newborn
- Male
- Middle Aged
- Risk Factors
- Sweden/epidemiology
- Other pharmacy
- Övrig farmaci
- PHARMACY
- FARMACI
- MEDICINE
- MEDICIN
- Gastroenterology
- Gastroenterologi
- Epidemiology
- Epidemiologi
- Pharmaceutical Pharmacology
- Farmaceutisk farmakologi
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas