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Genetic variation i...
Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample
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- Lind, Lars (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Penell, Johanna (författare)
- Uppsala universitet,Arbets- och miljömedicin
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- Syvänen, Ann-Christine (författare)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Axelsson, Tomas (författare)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Ingelsson, Erik (författare)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Morris, Andrew P. (författare)
- Wellcome Trust Ctr Human Genet, Univ Oxford, Oxford, England
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- Lindgren, Cecilia (författare)
- Wellcome Trust Ctr Human Genet, Univ Oxford, Oxford, England
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- Salihovic, Samira, 1985- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- van Bavel, Bert, 1963- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Lind, P Monica (författare)
- Uppsala universitet,Arbets- och miljömedicin
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Environmental Research. - : Elsevier BV. - 0013-9351 .- 1096-0953. ; 133, s. 135-140
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. We evaluated if circulating levels of PCBs in a population sample were related to genetic variation in the genes encoding these CYPs. In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (1016 subjects all aged 70), 21 SNPs in the CYP1A1, CYP1A2 and CYP1B1 genes were genotyped. Sixteen PCB congeners were analysed by high-resolution chromatography coupled to high-resolution mass spectrometry (HRGC/ HRMS). Of the investigated relationships between SNPs in the CYP1A1, CYP1A2 and CYP1B1 and six PCBs (congeners 118, 126, 156, 169, 170 and 206) that captures > 80% of the variation of all PCBs measured, only the relationship between CYP1A1 rs2470893 was significantly related to PCB118 levels following strict adjustment for multiple testing (p=0.00011). However, there were several additional SNPs in the CYP1A2 and CYP1B1 that showed nominally significant associations with PCB118 levels (p-values in the 0.003-0.05 range). Further, several SNPs in the CYP1B1 gene were related to both PCB156 and PCB206 with p-values in the 0.005-0.05 range. Very few associations with p < 0.05 were seen for PCB126, PCB169 or PCB170. Genetic variation in the CYP1A1 was related to circulating PCB118 levels in the general elderly population. Genetic variation in CYP1A2 and CYP1B1 might also be associated with other PCBs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Gene
- SNP
- CYP
- PCB
- Metabolism
- Epidemiology
- Enviromental Science
- Miljövetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lind, Lars
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Penell, Johanna
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Syvänen, Ann-Chr ...
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Axelsson, Tomas
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Ingelsson, Erik
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Morris, Andrew P ...
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visa fler...
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Lindgren, Cecili ...
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Salihovic, Samir ...
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van Bavel, Bert, ...
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Lind, P Monica
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Environmental Re ...
- Av lärosätet
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Örebro universitet
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Uppsala universitet