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The influence of UV...
The influence of UV exposure on 5-aminolevulinic acid-induced protoporphyrin IX production in skin
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- von Beckerath, Mathias, 1966- (författare)
- Department of Otolaryngology, Örebro Medical Center Hospital, Örebro, Sweden
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- Juzenas, Petras (författare)
- Biophysics Department, The Norwegian Radium Hospital, Oslo, Norway; 3Laser Research Center, Vilnius University, Vilnius, Lithuania
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- Ma, Li-Wei (författare)
- Biophysics Department, The Norwegian Radium Hospital, Oslo, Norway
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- Iani, Vladimir (författare)
- Biophysics Department, The Norwegian Radium Hospital, Oslo, Norway
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- Lofgren, Lennart (författare)
- Department of Otolaryngology,Örebro Medical Center Hospital, Örebro, Sweden
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- Moan, Johan (författare)
- Biophysics Department, The Norwegian Radium Hospital, Oslo, Norway
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(creator_code:org_t)
- 2001
- 2001
- Engelska.
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Ingår i: Photochemistry and Photobiology. - 0031-8655 .- 1751-1097. ; 74:6, s. 825-828
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The skin of nude mice was exposed to erythemogenic doses of UV radiation, which resulted in erythema with edema. An ointment containing 5-aminolevulinic acid (ALA) was topically applied on mouse and human skin. Differences in the kinetics of protoporphyrin accumulation were investigated in normal and UV-exposed skin. At 24 and 48 h after UV exposure, skin produced significantly less protoporphyrin IX (PpIX) than skin unexposed to UV. Human skin on body sites frequently exposed to solar radiation (the lower arm) also produced less PpIX than skin exposed more rarely to the sun (the upper arm). It is concluded that UV radiation introduces persisting changes in the skin, relevant to its capability of producing PpIX from ALA. The observed differences in ALA-induced PpIX fluorescence may be the result of altered penetration of ALA through the stratum corneum or altered metabolizing ability of normal and UV-exposed skin (or both).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Molekylär cellbiologi
- Molecular Cellbiology
- Microbiology
- Mikrobiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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