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- Zhou, ZhenState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, China (författare)
Highly elevated serum concentrations of perfluoroalkyl substances in fishery employees from tangxun lake, China.
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
- 2014-03-18
- American Chemical Society (ACS),2014
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-38400
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-38400URI
- https://doi.org/10.1021/es4057467DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-193869URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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Anmärkningar
- Sponsors:National Key Basic Research Program of China Grant no 2014CB114402 National Natural Science Foundation of China Grant no:s 41023005 21377145 21321004State Environmental Protection Welfare Scientific Research Project Grant no 201009026Program for New Century Excellent Talents in University Grant no NCET-11-0964
- Increasing production and use of per- and polyfluoroalkyl substances (PFASs) has been reported from China, and a few studies have shown there are subpopulations in China with high and increasing exposure to these chemicals. In this paper, we present a comprehensive exposure assessment of PFASs in fishery employees from Tangxun Lake, China. Exceptionally high serum concentrations of C4 to C12 PFASs were observed in fishery employees (n = 39, median perfluorooctanesulfonic acid (PFOS) 10 400 ng/mL) compared to a reference group from the same city (n = 9, median PFOS 18.7 ng/mL). On the basis of the comparison of different exposure pathways, it was concluded that contaminated fish from Tangxun Lake was the primary source of PFAS exposure to fishery employees, and there was a positive association between serum PFAS concentrations and time of employment in the fishery. PFOS isomer profiles in fishery employees showed a significantly higher proportion of linear PFOS (78.4%) compared to the background-exposed reference group (66.8%), reflecting the highly linear PFOS isomer profile (>90%) of lake fish. Median renal clearance rates (CLrenal) of C4 to C10 perfluoroalkyl carboxylic acids (PFCAs) and perfluoroalkanesulfonic acids (PFSAs) ranged from 0.020 to 16.5 mL/day/kg and 0.013 to 9.43 mL/day/kg, respectively. PFCAs with less than eight perfluoroalkyl carbons were primarily eliminated via urine, whereas other routes of excretion may have contributed to the elimination for long-chain PFCAs and PFSAs. Calculated daily PFOS exposures of fishery employees significantly exceeded tolerable daily intake limits, but clinical blood chemistry parameters were mostly within normal reference ranges. However, additional epidemiological studies are needed to address potential associations between PFAS exposure and health effects in the Tangxun Lake area.
Ämnesord och genrebeteckningar
- NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
- NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
- Alkanesulfonic Acids; Animals; Aquatic Organisms; Carboxylic Acids; China; Environmental Monitoring; Female; Fisheries; Fluorocarbons; Humans; Kidney; Lakes; Male; Occupational Exposure; Risk Assessment
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Shi, YaliState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, China (författare)
- Vestergren, RobinNorwegian Institute for Air Research (NILU), Tromsø, Norway (författare)
- Wang, Thanh,1979-State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, China(Swepub:liu)thawa68 (författare)
- Liang, YongSchool of Medicine, Jianghan University, Wuhan, China; Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan, China (författare)
- Cai, YaqiState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, China (författare)
- State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Science, Chinese Academy of Sciences, Beijing, ChinaNorwegian Institute for Air Research (NILU), Tromsø, Norway (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Environmental Science and Technology: American Chemical Society (ACS)48:7, s. 3864-38740013-936X1520-5851
Internetlänk
- https://ir.rcees.ac.cn/bitstream/311016/9381/1/Highly%20Elevated%20Serum%20Concentrations%20of%20Perfluoroalkyl%20Substances%20in%20Fishery%20Employees%20from%20Tangxun%20Lake%2c%20China.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-38400
- https://doi.org/10.1021/es4057467
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-193869
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