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Sökning: onr:"swepub:oai:DiVA.org:oru-38714" > Biomarker Discovery...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006024naa a2200661 4500
001oai:DiVA.org:oru-38714
003SwePub
008141118s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-120037
009oai:DiVA.org:uu-183399
009oai:prod.swepub.kib.ki.se:125896989
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-387142 URI
0247 a https://doi.org/10.1158/1078-0432.CCR-12-11392 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1200372 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1833992 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1258969892 URI
040 a (SwePub)orud (SwePub)umud (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Botling, Johanu Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)johanbot
2451 0a Biomarker Discovery in Non-Small Cell Lung Cancer :b Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation
264 1c 2013
338 a print2 rdacarrier
500 a Funding agencies are:Swedish Cancer Society  Lions Cancer Foundation, Uppsala, Sweden  German Research Foundation (DFG) RA 870/4-1, RA 870/5-1 Astra Zeneca  Knut and Alice Wallenberg Foundation 
520 a Purpose: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multigene signatures in clinical practice is unclear, and the biologic importance of individual genes is difficult to assess, as the published signatures virtually do not overlap.Experimental Design: Here, we describe a novel single institute cohort, including 196 non-small lung cancers (NSCLC) with clinical information and long-term follow-up. Gene expression array data were used as a training set to screen for single genes with prognostic impact. The top 450 probe sets identified using a univariate Cox regression model (significance level P < 0.01) were tested in a meta-analysis including five publicly available independent lung cancer cohorts (n = 860).Results: The meta-analysis revealed 14 genes that were significantly associated with survival (P < 0.001) with a false discovery rate < 1%. The prognostic impact of one of these genes, the cell adhesion molecule 1 (CADM1), was confirmed by use of immunohistochemistry on tissue microarrays from 2 independent NSCLC cohorts, altogether including 617 NSCLC samples. Low CADM1 protein expression was significantly associated with shorter survival, with particular influence in the adenocarcinoma patient subgroup.Conclusions: Using a novel NSCLC cohort together with a meta-analysis validation approach, we have identified a set of single genes with independent prognostic impact. One of these genes, CADM1, was further established as an immunohistochemical marker with a potential application in clinical diagnostics. Clin Cancer Res; 19(1); 194-204. (c) 2012 AACR.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Onkologi
653 a Oncology
653 a Pathology
7001 a Edlund, Karolinau Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)kaedl086
7001 a Lohr, Miriamu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut
7001 a Hellwig, Birteu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut
7001 a Holmberg, Larsu Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)larsholmb
7001 a Lambe, Mats G.u Karolinska Institutet4 aut
7001 a Berglund, Andersu Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)andbe182
7001 a Ekman, Simonu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)simoekma
7001 a Bergqvist, Michaelu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)michberg
7001 a Pontén, Fredriku Uppsala universitet,Molekylär och morfologisk patologi,Pontén4 aut0 (Swepub:uu)fredpont
7001 a König, Andréu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut
7001 a Fernandes, Oswaldou Cardiothoracic Surgery, Örebro University Hospital, Örebro, Sweden4 aut
7001 a Karlsson, Matsu Region Örebro län,Laboratory Medicine4 aut0 (Swepub:oru)mskn
7001 a Helenius, Giselau Region Örebro län,Laboratory Medicine4 aut0 (Swepub:oru)ghs
7001 a Karlsson, Christina,d 1968-u Örebro universitet, Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)ckn
7001 a Rahnenfuehrer, Jörgu Department of Statistics, TU Dortmund University, Dortmund, Germany4 aut
7001 a Hengstler, Jan G.u Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany4 aut
7001 a Micke, Patricku Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)patmi676
7102 a Uppsala universitetb Molekylär och morfologisk patologi4 org
7730 t Clinical Cancer Researchg 19:1, s. 194-204q 19:1<194-204x 1078-0432x 1557-3265
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-38714
8564 8u https://doi.org/10.1158/1078-0432.CCR-12-1139
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120037
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183399
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125896989

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