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Electrochemotherapy...
Electrochemotherapy - possible benefits and limitations to its use in the head and neck region
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- Landström, Fredrik, 1966- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital, Örebro, Sweden
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- Reizenstein, Johan (författare)
- Örebro University Hospital, Örebro, Sweden
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- Nilsson, Christer (författare)
- Örebro University Hospital, Örebro, Sweden
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- von Beckerath, Mathias, 1966- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Löfgren, Lennart, 1939- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Adamsson, Gun-Britt (författare)
- Örebro University Hospital, Örebro, Sweden
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- Möller, Claes, 1950- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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(creator_code:org_t)
- 2014-12-15
- 2015
- Engelska.
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Ingår i: Acta Oto-Laryngologica. - : Informa Healthcare. - 0001-6489 .- 1651-2251. ; 135:1, s. 90-95
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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