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Electrochemotherapy...
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Landström, Fredrik,1966-Örebro universitet,Institutionen för hälsovetenskap och medicin,Örebro University Hospital, Örebro, Sweden
(författare)
Electrochemotherapy - possible benefits and limitations to its use in the head and neck region
- Artikel/kapitelEngelska2015
Förlag, utgivningsår, omfång ...
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2014-12-15
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Informa Healthcare,2015
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-39848
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-39848URI
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https://doi.org/10.3109/00016489.2014.947655DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding agency: Genetronics Inc., San Diego, CA, USA
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Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Reizenstein, JohanÖrebro University Hospital, Örebro, Sweden
(författare)
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Nilsson, ChristerÖrebro University Hospital, Örebro, Sweden
(författare)
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von Beckerath, Mathias,1966-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)msvt
(författare)
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Löfgren, Lennart,1939-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)ltln
(författare)
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Adamsson, Gun-BrittÖrebro University Hospital, Örebro, Sweden
(författare)
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Möller, Claes,1950-Örebro universitet,Institutionen för hälsovetenskap och medicin(Swepub:oru)cmr
(författare)
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Örebro universitetInstitutionen för hälsovetenskap och medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Oto-Laryngologica: Informa Healthcare135:1, s. 90-950001-64891651-2251
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