Sökning: onr:"swepub:oai:DiVA.org:oru-39949" >
A combined DNA-micr...
A combined DNA-microarray and mechanism-specific toxicity approach with zebrafish embryos to investigate the pollution of river sediments
-
- Kosmehl, Thomas (författare)
- Aquatic Ecology and Toxicology Group, COS–Center for Organismal Studies, University of Heidelberg, Heidelberg, Germany
-
- Otte, Jens (författare)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
-
- Yang, Lixin (författare)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
-
visa fler...
-
- Legradi, Jessica (författare)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
-
- Bluhm, Kerstin (författare)
- Department of Ecosystem Analysis, Institute for Environmental Research (Biology V), RWTH Aachen University, Aachen, Germany
-
- Zinsmeister, Christian (författare)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
-
- Keiter, Steffen, 1971- (författare)
- Department of Ecosystem Analysis, Institute for Environmental Research (Biology V), RWTH Aachen University, Aachen, Germany,MTM
-
- Reifferscheid, Georg (författare)
- German Federal Institute for Hydrology (BfG), Koblenz, Germany
-
- Manz, Werner (författare)
- Institute of Integrated Natural Sciences, University of Koblenz-Landau, Koblenz, Germany
-
- Braunbeck, Thomas (författare)
- Aquatic Ecology and Toxicology Group, COS–Center for Organismal Studies, University of Heidelberg, Heidelberg, Germany
-
- Strähle, Uwe (författare)
- Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany
-
- Hollert, Henner (författare)
- Department of Ecosystem Analysis, Institute for Environmental Research (Biology V), RWTH Aachen University, Aachen, Germany
-
visa färre...
-
(creator_code:org_t)
- Oxford, United Kingdom : Elsevier, 2012
- 2012
- Engelska.
-
Ingår i: Reproductive Toxicology. - Oxford, United Kingdom : Elsevier. - 0890-6238 .- 1873-1708. ; 33:2, s. 245-253
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The zebrafish embryo has repeatedly proved to be a useful model for the analysis of effects by environmental toxicants. This proof-of-concept study was performed to investigate if an approach combining mechanism-specific bioassays with microarray techniques can obtain more in-depth insights into theecotoxicity of complex pollutant mixtures as present, e.g., in sediment extracts. For this end, altered gene expression was compared to data from established bioassays as well as to results from chemical analysis. Mechanism-specific biotests indicated a defined hazard potential of the sediment extracts, and microarray analysis revealed several classes of significantly regulated genes which could be related to the hazard potential. Results indicate that potential classes of contaminants can be assigned to sediment extracts by both classical biomarker genes and corresponding expression profile analyses of known substances. However, it is difficult to distinguish between specific responses and more universal detoxification of the organism.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Microarray
- Transcriptomics
- Zebrafish
- Sediment extract
- Comet assay
- EROD assay
- Ames test
- Neutral red assay
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kosmehl, Thomas
-
Otte, Jens
-
Yang, Lixin
-
Legradi, Jessica
-
Bluhm, Kerstin
-
Zinsmeister, Chr ...
-
visa fler...
-
Keiter, Steffen, ...
-
Reifferscheid, G ...
-
Manz, Werner
-
Braunbeck, Thoma ...
-
Strähle, Uwe
-
Hollert, Henner
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Geovetenskap och ...
-
och Miljövetenskap
- Artiklar i publikationen
-
Reproductive Tox ...
- Av lärosätet
-
Örebro universitet