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Synthesis and Biolo...
Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization
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- Tengdelius, Mattias (författare)
- Linköpings universitet,Kemi,Tekniska högskolan
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- Lee, Chyan-Jang (författare)
- Linköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan
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- Grenegård, Magnus, 1963- (författare)
- Linköpings universitet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Integrative Regenerative Medicine Center (IGEN), Linköping University, Linköping, Sweden,Cardiovascular Research Center,Avdelningen för läkemedelsforskning,Hälsouniversitetet
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- Griffith, May (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet
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- Påhlsson, Peter (författare)
- Linköpings universitet,Avdelningen för cellbiologi,Hälsouniversitetet
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- Konradsson, Peter (författare)
- Linköpings universitet,Kemi,Tekniska högskolan
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(creator_code:org_t)
- 2014-06-10
- 2014
- Engelska.
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Ingår i: Biomacromolecules. - Washington, USA : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 15:7, s. 2359-2368
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- The sulfated marine polysaccharide fucoidan has been reported to have health benefits ranging from antivirus and anticancer properties to modulation of high blood pressure. Hence, they could enhance the biological function of materials for biomedical applications. However, the incorporation of fucoidan into biomaterials has been difficult, possibly due to its complex structure and lack of suitable functional groups for covalent anchoring to biomaterials. We have developed an approach for a rapid synthesis of fucoidanmimetic glycopolymer chains through cyanoxyl-mediated freeradical polymerization, a method suitable for chain-end functionalizing and subsequent linkage to biomaterials. The resulting sulfated and nonsulfated methacrylamido α-L-fucoside glycopolymers’ fucoidan-mimetic properties were studied in HSV-1 infection and platelet activation assays. The sulfated glycopolymer showed similar properties to natural fucoidan in inducing platelet activation and inhibiting HSV-1 binding and entry to cells, thus indicating successful syntheses of fucoidan-mimetic glycopolymers.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- NATURVETENSKAP -- Fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences (hsv//eng)
Nyckelord
- Biomedicin
- Biomedicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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