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Randomized controll...
Randomized controlled study in pregnancy on treatment of marked hyperglycemia that is short of overt diabetes
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- Fadl, Helena E., 1965- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Univ Orebro, Sch Hlth & Med Sci, Dept Obstet & Gynecol, SE-70182 Orebro, Sweden.
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- Gärdefors, Susanne (författare)
- Department of Obstetrics and Gynecology, School of Health and Medical Sciences, Örebro University, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, Dept Obstet & Gynecol, SE-70182 Orebro, Sweden.
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- Hjertberg, Ragnhild (författare)
- UltraGyn Clinic, Stockholm, Sweden
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- Nord, Eva (författare)
- Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Univ Hosp, Dept Obstet & Gynecol, Stockholm, Sweden.
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- Persson, Bengt (författare)
- Karolinska Institute, Stockholm, Sweden,Karolinska Inst, Stockholm, Sweden.
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- Schwarcz, Erik (författare)
- Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, Dept Internal Med, SE-70182 Orebro, Sweden.
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- Åman, Jan, 1948- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Pediatrics, Örebro University Hospital, Örebro, Sweden,Univ Orebro, Sch Hlth & Med Sci, Dept Pediat, SE-70182 Orebro, Sweden.
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- Östlund, Ingrid K., 1951- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin
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- Hanson, Ulf S. B., 1944- (författare)
- Uppsala universitet,Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Children’s and Women’s Health, Uppsala University, Uppsala, Sweden,Obstetrik & gynekologi,Univ Orebro, Sch Hlth & Med Sci, Dept Obstet & Gynecol, SE-70182 Orebro, Sweden.
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(creator_code:org_t)
- 2015-08-29
- 2015
- Engelska.
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Ingår i: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley-Blackwell. - 0001-6349 .- 1600-0412. ; 94:11, s. 1181-1187
- Relaterad länk:
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https://obgyn.online...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: A randomized multicenter study was conducted in the Stockholm-orebro areas in Sweden to evaluate how treatment aiming at normoglycemia affects fetal growth, pregnancy and neonatal outcome in pregnant women with severe hyperglycemia.Material and methods: Pregnant women with hyperglycemia defined as fasting capillary plasma glucose <7.0 mmol/L and a two-hour plasma glucose value 10.0 and <12.2 mmol/L following a 75-g oral glucose tolerance test (OGTT) diagnosed before 34 weeks of gestation were randomized to treatment (n=33) or controls (n=36). Women assigned to the control group were blinded for the OGTT results and received routine care. The therapeutic goal was fasting plasma glucose 4-5 mmol/L, and <6.5 mmol/L after a meal. Primary outcomes were size at birth and number of large-for-gestational age (>90th percentile) neonates. Secondary outcomes were pregnancy complications, neonatal morbidity and glycemic control.Results: The planned number of participating women was not reached. There was a significantly reduced rate of large-for-gestational age neonates, 21 vs. 47%, P<0.05. Group differences in pregnancy complications and neonatal morbidity were not detected because of limited statistical power. In total, 66.7% of the women in the intervention group received insulin. Of all measured plasma glucose values, 64.1% were in the target range, 7.2% in the hypoglycemic range and 28.7% above target values. There were no cases of severe hypoglycemia.Conclusions: Aiming for normalized glycemia in a pregnancy complicated by severe hyperglycemia reduces fetal growth but is associated with an increased rate of mild hypoglycemia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Pregnancy
- gestational diabetes mellitus
- hyperglycemia
- treatment
- birthweight
- compliance
- large-for-gestational age
- Obstetrik och gynekologi
- Obstetrics and Gynaecology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Fadl, Helena E., ...
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Gärdefors, Susan ...
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Hjertberg, Ragnh ...
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Nord, Eva
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Persson, Bengt
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Schwarcz, Erik
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visa fler...
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Åman, Jan, 1948-
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Östlund, Ingrid ...
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Hanson, Ulf S. B ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
- Artiklar i publikationen
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Acta Obstetricia ...
- Av lärosätet
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Örebro universitet
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Uppsala universitet
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Karolinska Institutet