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Hydroxyl radical - ...
Hydroxyl radical - thymine adduct induced DNA damages
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Schyman, Patric (författare)
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- Eriksson, Leif A. (författare)
- Örebro universitet,Institutionen för naturvetenskap,Biophysical Chemistry
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Zhang, Ru bo (författare)
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Laaksonen, Aatto (författare)
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(creator_code:org_t)
- Amsterdam : Elsevier, 2008
- 2008
- Engelska.
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Ingår i: Chemical Physics Letters. - Amsterdam : Elsevier. - 0009-2614 .- 1873-4448. ; 458:1-3, s. 186-189
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- DNA damages caused by a 5-hydroxy-5,6-dihydrothymine-6-yl radical (5-OHT-6yl) abstracting a C20 hydrogen from a neighboring sugar (inter-H abstraction) have been theoretically investigated using hybrid DFT in gas phase and in water solution. The inter-H abstraction was here shown to be comparable in energy (24 kcal mol 1) with the intra-H abstraction in which the 5-OHT-6yl abstracts a C20 hydrogen from its own sugar. The effect of a neutrally or a negatively charged phosphate group was also studied and the results show no significant impact on the activation energy of the hydrogen abstraction whereas base release and strand break reactions are affected.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- NATURAL SCIENCES
- NATURVETENSKAP
- Chemistry
- Kemi
- Physical chemistry
- Fysikalisk kemi
- kemi
- Chemistry
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- art (ämneskategori)
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