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Thrombus aspiration...
Thrombus aspiration in patients with large anterior myocardial infarction : A Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia trial substudy
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- Calais, Fredrik, 1971- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Department of Cardiology, Örebro University Hospital, Örebro, Sweden,Univ Orebro, Fac Hlth, Dept Cardiol, S-70362 Orebro, Sweden.
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- Lagerqvist, Bo (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
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- Leppert, Jerzy (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Centre for Clinical Research, Uppsala University, Central Hospital, Västerås, Sweden
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- James, Stefan K. (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
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- Fröbert, Ole, 1964- (författare)
- Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden,Univ Orebro, Fac Hlth, Dept Cardiol, S-70362 Orebro, Sweden.
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- Engelska.
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Ingår i: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 172:2, s. 129-134
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: The TASTE trial did not demonstrate clinical benefit of thrombus aspiration (TA). High-risk patients might benefit from TA.Methods: The TASTE trial was a multicenter, randomized, controlled, open-label trial obtaining end points from national registries. Patients (n = 7,244) with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) were randomly assigned 1: 1 to TA and PCI or to PCI alone. We assessed the 1-year clinical effect of TA in a subgroup with potentially large anterior STEMI: mid or proximal left anterior descending coronary artery infarct lesion, thrombolysis in myocardial infarction 0 to 2 flow, and symptom onset to PCI time = 5 hours. In this substudy, patient eligibility criteria corresponded to that of the INFUSE-AMI study.Results: In total, 1,826 patients fulfilled inclusion criteria. All-cause mortality at 1 year of patients randomized to TA did not differ from those randomized to PCI only (hazard ratio [HR] 1.05, 95% CI 0.74-1.49, P = .77). Rates of rehospitalization for myocardial infarction, heart failure, and stent thrombosis did not differ between groups (HR 0.87, 95% CI 0.51-1.46, P = .59; HR 1.10 95% CI 0.77-1.58, P = .58; and HR 0.75, 95% CI 0.30-1.86, P = .53, respectively). This was also the case for the combined end point of all-cause mortality and rehospitalization for myocardial infarction, heart failure, or stent thrombosis (HR 1.00, 95% CI 0.79-1.26, P = .99).Conclusion: In patients with STEMI and large area of myocardium at risk, TA did not affect outcome within 1 year.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cardiology
- Kardiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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