Sökning: onr:"swepub:oai:DiVA.org:oru-49331" > Analysis of five ch...
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000 | 13285naa a2200961 4500 | |
001 | oai:DiVA.org:oru-49331 | |
003 | SwePub | |
008 | 160315s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:133467000 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-493312 URI |
024 | 7 | a https://doi.org/10.1038/ng.35282 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1334670002 URI |
040 | a (SwePub)orud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ellinghaus, Davidu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
245 | 1 0 | a Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci |
264 | c 2016-03-14 | |
264 | 1 | a New York, USA :b Nature Publishing Group,c 2016 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:German Federal Ministry of Education and Research (BMBF) 01ZX1306AEstonian Research Council IUT20-60Center of Excellence in Genomics (EXCEGEN)University of Tartu (SP1GVARENG)UK Department of Health via National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre awards to Guy's and St Thomas' National Health Service (NHS) Foundation TrustKing's College LondonUniversity of CambridgeGerman Federal Ministry of Education and Research (BMBF), within the context of National Genome Research Network 2 (NGFN-2)National Genome Research Network plus (NGFNplus)Integrated Genome Research Network (IG) MooDS 01GS08144 01GS08147Netherlands Organization for Scientific Research (NWO) 016.136.308US NIH 1R01AR063759 5U01GM092691-05 1UH2AR067677-01 U19AI111224-01 1R01DK084960-05Doris Duke Charitable Foundation 2013097Novo Nordisk Foundation NNF14CC0001H2020 project MedBioinformatics 634143Norwegian PSC Research Center | |
520 | a We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. The comorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity). In particular, the strong comorbidity between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease, which is genetically distinct from classical inflammatory bowel disease phenotypes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Genetik | |
653 | a Genetics | |
700 | 1 | a Jostins, Lukeu Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 aut |
700 | 1 | a Spain, Sarah L.u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 aut |
700 | 1 | a Cortes, Adrianu Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Bethune, Jörnu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
700 | 1 | a Han, Buhmu Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea4 aut |
700 | 1 | a Park, Yu Rangu Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea4 aut |
700 | 1 | a Raychaudhuri, Soumyau Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States4 aut |
700 | 1 | a Pouget, Jennie G.u Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada4 aut |
700 | 1 | a Hübenthal, Matthiasu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
700 | 1 | a Folseraas, Trineu Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway4 aut |
700 | 1 | a Wang, Yunpengu Department of Neurosciences, University of California, San Diego, USA4 aut |
700 | 1 | a Esko, Tonuu Estonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology, Boston Children's Hospital, Cambridge MA, USA; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, USA4 aut |
700 | 1 | a Metspalu, Andresu Estonian Genome Center, University of Tartu, Tartu, Estonia4 aut |
700 | 1 | a Westra, Harm-Janu Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States; Department of Medicine, Harvard Medical School, Boston MA, United States4 aut |
700 | 1 | a Franke, Ludeu University Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Pers, Tune H.u Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, United States; Novo Nordisk Foundation, Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark4 aut |
700 | 1 | a Weersma, Rinse K.u Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a Collij, Valerieu Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands4 aut |
700 | 1 | a D'Amato, Maurou Karolinska Institutet4 aut |
700 | 1 | a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)jshn |
700 | 1 | a Jensen, Anders Boecku Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut |
700 | 1 | a Lieb, Wolfgangu Institute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany; PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany4 aut |
700 | 1 | a Degenhardt, Franziskau Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut |
700 | 1 | a Forstner, Andreas J.u Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut |
700 | 1 | a Hofmann, Andreau Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut |
700 | 1 | a The International IBD Genetics Consortium, (IIBDGC)4 aut |
700 | 1 | a International Genetics of Ankylosing Spondylitis Consortium, (IGAS)4 aut |
700 | 1 | a International PSC Study Group, (IPSCSG)4 aut |
700 | 1 | a Genetic Analysis of Psoriasis Consortium, (GAPC)4 aut |
700 | 1 | a Psoriasis Association Genetics Extension, (PAGE)4 aut |
700 | 1 | a Schreiber, Stefanu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut |
700 | 1 | a Mrowietz, Ulrichu Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
700 | 1 | a Juran, Brian D.u Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA4 aut |
700 | 1 | a Lazaridis, Konstantinos N.u Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA4 aut |
700 | 1 | a Brunak, Sørenu Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut |
700 | 1 | a Dale, Anders M.u Department of Neurosciences, University of California, San Diego, USA; Department of Radiology, University of California, San Diego, USA4 aut |
700 | 1 | a Trembath, Richard C.u Division of Genetics and Molecular Medicine, King's College London, London, UK4 aut |
700 | 1 | a Weidinger, Stephanu Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
700 | 1 | a Weichenthal, Michaelu Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
700 | 1 | a Ellinghaus, Evau Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
700 | 1 | a Elder, James T.u Department of Dermatology, University of Michigan, Ann Arbor, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, USA4 aut |
700 | 1 | a Barker, Jonathan N. W. N.u St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK4 aut |
700 | 1 | a Andreassen, Ole A.u NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital Ullevål, Oslo, Norway4 aut |
700 | 1 | a McGovern, Dermot P.u F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, USA; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, USA4 aut |
700 | 1 | a Karlsen, Tom H.u Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway4 aut |
700 | 1 | a Barrett, Jeffrey C.u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 aut |
700 | 1 | a Parkes, Milesu Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Brown, Matthew A.u University of Queensland Diamantina Institute, Translational Research Institute, Brisbane QLD, Australia; Institute of Health and Biomedical Innovation (IHBI), Translational Research Institute, Queensland University of Technology (QUT), Brisbane QLD, Australia4 aut |
700 | 1 | a Franke, Andreu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut |
710 | 2 | a Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germanyb Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 org |
773 | 0 | t Nature Geneticsd New York, USA : Nature Publishing Groupg 48:5, s. 510-518q 48:5<510-518x 1061-4036x 1546-1718 |
856 | 4 | u https://europepmc.org/articles/pmc4848113?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49331 |
856 | 4 8 | u https://doi.org/10.1038/ng.3528 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133467000 |
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