Association between background exposure to organochlorine pesticides and the risk of cognitive impairment: A prospective study that accounts for weight change

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Lee, Duk-HeeDepartment of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Republic of Korea,Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea.;Kyungpook Natl Univ, Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea. (författare)

Association between background exposure to organochlorine pesticides and the risk of cognitive impairment : A prospective study that accounts for weight change

Artikel/kapitelEngelska2016

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Oxford, United Kingdom :Elsevier,2016
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LIBRIS-ID:oai:DiVA.org:oru-49641
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49641URI
https://doi.org/10.1016/j.envint.2016.02.001DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-297129URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Funding Agency:Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea HI13C0715
Background: Background exposure to organochlorine (OC) pesticides was recently linked to cognitive impairment and dementia in cross-sectional and case-control studies. This prospective study was performed to evaluate if OC pesticides at baseline are associated with the future risk of cognitive impairment in elderly, with particular focus on weight change.Methods: Plasma concentrations of 3 OC pesticides (p,p'-DDE, trans-nonachlor, and hexachlorobenzene) were measured among 989 men and women aged 70years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). Cognitive impairment was validated by reviewing medical records. During the ten year follow-up, cognitive impairment was developed in 75 subjects. When weight change from age 70 to 75 was considered in analyses, elderly with incident cases before age 75 were excluded to keep the prospective perspective, leaving 795 study subjects and 44 incident cases.Results: The summary measure of 3 OC pesticides predicted the development of cognitive impairment after adjusting for covariates, including weight change. Compared to subjects with OC pesticides <25th percentile, adjusted hazard ratios (HRs) in those with 25th-<75th and ≥75th percentiles were 3.5 (95% confidence interval: 1.5-8.5) and 3.2 (1.1-7.6), respectively (Ptrend=0.04). Among 506 subjects who maintained or gained body weight, adjusted HRs were 6.9 and 11.6 (1.4-92.6) among the elderly in the 25th-<75th and ≥75th percentiles compared to <25th percentile (Ptrend<0.01).Conclusions: This prospective study demonstrates that background exposure to OC pesticides are linked to the risk of developing cognitive impairment in elderly. The role of the chronic exposure to low dose OC pesticides in the development of dementia should be further evaluated in other populations.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
Cognition
dementia
organochlorine pesticides
Persistent organic pollutants
weight loss
Enviromental Science
Miljövetenskap

Biuppslag (personer, institutioner, konferenser, titlar ...)

Lind, P. MonicaUppsala universitet,Arbets- och miljömedicin(Swepub:uu)monilind (författare)
Jacobs, David R.,JrDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis MN, United States,Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA. (författare)
Salihovic, Samira,1985-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Univ Orebro, Sch Sci & Technol, MTM Res Ctr, SE-70182 Orebro, Sweden.(Swepub:uu)samsa560 (författare)
van Bavel, Bert,1963-Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Univ Orebro, Sch Sci & Technol, MTM Res Ctr, SE-70182 Orebro, Sweden.(Swepub:oru)bvl (författare)
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind (författare)
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Republic of KoreaKyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea.;Kyungpook Natl Univ, Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea. (creator_code:org_t)

Sammanhörande titlar

Ingår i:Environment InternationalOxford, United Kingdom : Elsevier89-90, s. 179-1840160-41201873-6750

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