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Short-and long-term...
Short-and long-term individual variation in NT-proBNP levels in patients with stable coronary artery disease
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- Nordenskjöld, Anna M., 1977- (författare)
- Region Örebro län,Department of Cardiology
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- Ahlström, Håkan (författare)
- Uppsala universitet,Enheten för radiologi
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- Eggers, Kai M. (författare)
- Uppsala universitet,Kardiologi
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- Fröbert, Ole (författare)
- Region Örebro län,Department of Cardiology
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- Venge, Per (författare)
- Uppsala universitet,Biokemisk struktur och funktion
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- Lindahl, Bertil (författare)
- Uppsala universitet,Kardiologi
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(creator_code:org_t)
- Elsevier, 2013
- 2013
- Engelska.
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Ingår i: Clinica Chimica Acta. - : Elsevier. - 0009-8981 .- 1873-3492. ; 422:25, s. 15-20
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: In addition to diagnosis of heart failure (HF) natriuretic peptides (BNP and NT-proBNP) may be used for risk prediction in stable and acute coronary artery disease. The aim of the study was to evaluate the short- and long-term individual variation of NT-proBNP in patients with stable coronary artery disease.Methods: Twenty-four patients with suspected stable coronary artery disease and scheduled for elective coronary angiography were included. Blood samples were drawn at enrolment and, on average 3 weeks later, serially the day prior to coronary angiography. NT-proBNP was determined using Elecsys proBNP sandwich immunoassay (Roche Diagnostics).Results: The individual variation in NT-proBNP over 4 h was 11.8%, over 20 h 12.4% and over 3 weeks 20.4%. The corresponding positive and negative lognormal reference change values (RCV) were +41/-29%, +42/-30% and + 76/-43%, respectively. No significant circadian variation was found.Conclusions: Our results suggest that an increase in NT-proBNP levels of >42% or a decrease of >30% is needed to indicate a reliable short-term change; and for a long-term change an increase of >76% or a decrease of >43% is required. This should be considered when interpreting changes in NT-proBNP levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- NT-proBNP
- Cardiovascular diseases/diagnosis
- Individual variation
- Reference change values
- Immunoassay
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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