Sökning: onr:"swepub:oai:DiVA.org:oru-50332" > High-density mappin...
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000 | 07676naa a2200637 4500 | |
001 | oai:DiVA.org:oru-50332 | |
003 | SwePub | |
008 | 160518s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:130633341 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-503322 URI |
024 | 7 | a https://doi.org/10.1038/ng.31762 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1306333412 URI |
040 | a (SwePub)orud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Goyette, Philippeu Research Center, Montreal Heart Institute, Montreal QC, Canada4 aut |
245 | 1 0 | a High-density mapping of the MHC identifies a shared role for HLA-DRB1*01 :b 03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis |
264 | c 2015-01-05 | |
264 | 1 | a New York, USA :b Nature Publishing Group,c 2015 |
338 | a print2 rdacarrier | |
520 | a Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD. | |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
700 | 1 | a Boucher, Gabrielleu Research Center, Montreal Heart Institute, Montreal QC, Canada4 aut |
700 | 1 | a Mallon, Dermotu Department of Surgery, University of Cambridge, Cambridge, UK; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK4 aut |
700 | 1 | a Ellinghaus, Evau Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany4 aut |
700 | 1 | a Jostins, Lukeu Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK; Christ Church, University of Oxford, Oxford, UK4 aut |
700 | 1 | a Huang, Hailiangu Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; Broad Institute of MIT and Harvard, Cambridge MA, USA4 aut |
700 | 1 | a Ripke, Stephanu Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; Broad Institute of MIT and Harvard, Cambridge MA, USA4 aut |
700 | 1 | a Gusareva, Elena S.u Systems and Modeling Unit, Montefiore Institute, University of Liege, Liege, Belgium; Bioinformatics and Modeling, GIGA-R (Groupe Interdisciplinaire de Génoprotéomique Appliquée) Research Center, University of Liege, Liege, Belgium4 aut |
700 | 1 | a Annese, Vitou Unit of Gastroenterology, IRCCS-CSS (Istituto di Ricovero e Cura a Carattere Scientifico–Casa Sollievo della Sofferenza) Hospital, San Giovanni Rotondo, Italy; Unit of Gastroenterology SOD2 (Strutture Organizzative Dipartimentali), Azienda Ospedaliero Universitaria (AOU) Careggi, Florence, Italy4 aut |
700 | 1 | a Hauser, Stephen L.u Department of Neurology, University of California, San Francisco, USA4 aut |
700 | 1 | a Oksenberg, Jorge R.u Department of Neurology, University of California,San Francisco, USA4 aut |
700 | 1 | a Thomsen, Ingou Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany4 aut |
700 | 1 | a Leslie, Stephenu Murdoch Children's Research Institute, Parkville Vic, Australia; Department of Mathematics and Statistics, University of Melbourne, Melbourne Vic, Australia4 aut |
700 | 1 | a Daly, Mark J.u Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA; Broad Institute of MIT and Harvard, Cambridge MA, USA4 aut |
700 | 1 | a Van Steen, Kristelu Systems and Modeling Unit, Montefiore Institute, University of Liege, Liege, Belgium; Bioinformatics and Modeling, GIGA-R (Groupe Interdisciplinaire de Génoprotéomique Appliquée) Research Center, University of Liege, Liege, Belgium4 aut |
700 | 1 | a Duerr, Richard H.u Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh PA, USA4 aut |
700 | 1 | a Barrett, Jeffrey C.u Wellcome Trust Sanger Institute, Hinxton, UK4 aut |
700 | 1 | a McGovern, Dermot P. B.4 aut |
700 | 1 | a Schumm, L. Philipu Department of Public Health Sciences, University of Chicago, Chicago ILL, USA4 aut |
700 | 1 | a Traherne, James A.u Cambridge Institute for Medical Research, Cambridge, UK; Department of Pathology, University of Cambridge, Cambridge, UK4 aut |
700 | 1 | a Carrington, Mary N.u Cancer and Inflammation Program, Laboratory of Experimental Immunology, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick MD, USA; Ragon Institute of Massachusetts General Hospital, MIT and Harvard, Cambridge MA, USA4 aut |
700 | 1 | a Kosmoliaptsis, Vasilisu Department of Surgery, University of Cambridge, Cambridge, UK; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK4 aut |
700 | 1 | a Karlsen, Tom H.u Research Institute of Internal Medicine, Department of Transplantation Medicine, Division of Cancer, Surgery and Transplantation, Oslo University Hospital (Rikshospitalet), Oslo, Norway; Norwegian Primary Sclerosing Cholangitis Research Center, Department of Transplantation Medicine, Division of Cancer, Surgery and Transplantation, Oslo University Hospital (Rikshospitalet), Oslo, Norway4 aut |
700 | 1 | a Franke, Andreu Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel, Germany4 aut |
700 | 1 | a Rioux, John D.u Research Center, Montreal Heart Institute, Montreal QC, Canada; Faculté de Médecine, Université de Montréal, Montreal QC, Canada4 aut |
700 | 1 | a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Örebro University Hospital, Örebro, Sweden4 ctb0 (Swepub:oru)jshn |
710 | 2 | a Research Center, Montreal Heart Institute, Montreal QC, Canadab Department of Surgery, University of Cambridge, Cambridge, UK; National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge, UK4 org |
773 | 0 | t Nature Geneticsd New York, USA : Nature Publishing Groupg 47:2, s. 172-179q 47:2<172-179x 1061-4036x 1546-1718 |
856 | 4 | u https://scholarlypublications.universiteitleiden.nl/access/item%3A2995139/view |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50332 |
856 | 4 8 | u https://doi.org/10.1038/ng.3176 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130633341 |
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