onr:"swepub:oai:DiVA.org:oru-51070"
Sökning: onr:"swepub:oai:DiVA.org:oru-51070" > Associations of uri...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Pan, YitaoKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China (författare)
Associations of urinary 5-methyl-2'-deoxycytidine and 5-hydroxymethyl-2'-deoxycytidine with phthalate exposure and semen quality in 562 Chinese adult men
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
- Oxford, United Kingdom :Elsevier,2016
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-51070
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-51070URI
- https://doi.org/10.1016/j.envint.2016.06.020DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Funding Agencies:National Basic Research Program of China (973) 2013CB945204Chinese Academy Of Sciences XDB14040202National Natural Science Foundation of China 21477127
- 5-methyl-2'-deoxycytidine (5mdC) and 5-hydroxymethyl-2'-deoxycytidine (5hmdC), products of DNA methylation and hydroxymethylation processes, have been detected previously in human urine, but their associations with environmental chemicals or healthy outcomes are unclear. The present investigation explored the associations between urinary 5mdC and 5hmdC with phthalate exposure and semen quality. We assessed semen parameters including sperm concentration, motility, and morphology, before measuring urinary 5mdC, 5hmdC and 13 phthalate metabolites among 562 subfertile men from Nanjing, China. Urinary 5mdC and 5hmdC were positively associated with the levels of low molecular weight phthalate metabolites (Low-MWP), high molecular weight phthalate metabolites (High-MWP), and the sum of all phthalate metabolites (ΣPAEs), respectively. Urinary 5mdC was associated with below-reference sperm concentration (odds ratios for increasing quartiles=1.0, 2.2, 3.0, 2.0; p for trend =0.02), sperm motility (1.0, 1.1, 1.9, 1.3; p for trend =0.05), and sperm morphology (1.0, 1.4, 2.3, 1.5; p for trend =0.05). Sperm concentration was associated with the highest quartile of urinary 5hmdC [odds ratio=1.9 (95% CI: 1.1, 3.6)]. Our findings showed significant associations between urinary 5mdC and 5hmdC with phthalate metabolites and semen parameters, which suggested urinary 5mdC and 5hmdC may be promising biomarkers in future epidemiological studies.
Ämnesord och genrebeteckningar
- NATURVETENSKAP Kemi Analytisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Analytical Chemistry hsv//eng
- NATURVETENSKAP Geovetenskap och miljövetenskap Miljövetenskap hsv//swe
- NATURAL SCIENCES Earth and Related Environmental Sciences Environmental Sciences hsv//eng
- DNA methylation
- hydroxymethylation
- 5mdC
- 5hmdC
- phthalate metabolites
- semen quality
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Jing, JunReproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China (författare)
- Yeung, Leo W. Y.,1981-Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM)(Swepub:oru)lyg (författare)
- Sheng, NanKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China (författare)
- Zhang, HongxiaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China (författare)
- Yao, BingReproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, PR China (författare)
- Dai, JiayinKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China (författare)
- Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR ChinaReproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Environment InternationalOxford, United Kingdom : Elsevier94, s. 583-5900160-41201873-6750
Internetlänk
Hitta via bibliotek
- Environment International (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Pan, Yitao
- Jing, Jun
- Yeung, Leo W. Y. ...
- Sheng, Nan
- Zhang, Hongxia
- Yao, Bing
- visa fler...
- Dai, Jiayin
- visa färre...
- Om ämnet
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Kemi
- och Analytisk kemi
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Geovetenskap och ...
- och Miljövetenskap
- Artiklar i publikationen
- Environment Inte ...
- Av lärosätet
- Örebro universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
