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Epigenome-wide anal...
Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature
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- Vymetalkova, Veronika (författare)
- Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Institute of Biology & Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic
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- Vodicka, Pavel (författare)
- Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Institute of Biology & Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pague, Czech Republic
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- Pardini, Barbara (författare)
- Human Genetics Foundation, (HuGeF), Torino, Italy
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- Rosa, Fabio (författare)
- Human Genetics Foundation, (HuGeF), Torino, Italy
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- Levy, Miroslav (författare)
- Department of Surgery, 1st Faculty of Medicine, Thomayer Hospital, Charles University, Prague, Czech Republic
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- Schneiderova, Michaela (författare)
- Department of Surgery, General University Hospital, Prague, Czech Republic
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- Liska, Vaclav (författare)
- Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Czech Republic; Department of Surgery, Teaching Hospital & Medical School in Pilsen, Charles University, Pilsen, Czech Republic
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- Vodickova, Ludmila (författare)
- Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Institute of Biology & Medical Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic; Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic
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- Nilsson, Torbjorn K. (författare)
- Umeå universitet,Klinisk kemi
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- Farkas, Sanja A., 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- London, United Kingdom : Future Medicine Ltd. 2016
- 2016
- Engelska.
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Ingår i: Epigenomics. - London, United Kingdom : Future Medicine Ltd.. - 1750-1911 .- 1750-192X. ; 8:9, s. 1193-1207
- Relaterad länk:
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https://iris.unito.i...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aim: The aim of the present study is to address a genome-wide search for novel methylation biomarkers in the rectal cancer (RC), as only scarce information on methylation profile is available.Materials and methods: We analyzed methylation status in 25 pairs of RC and adjacent healthy mucosa using the Illumina Human Methylation 450 BeadChip.Results: We found significantly aberrant methylation in 33 genes. After validation of our results by pyrosequencing, we found a good agreement with our findings. The BPIL3 and HBBP1 genes resulted hypomethylated in RC, whereas TIFPI2, ADHFE1, FLI1 and TLX1 were hypermethylated. An external validation by TCGA datasets confirmed the results.Conclusion: Our study, with external validation, has demonstrated the feasibility of using specific methylated DNA signatures for developing biomarkers in RC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
Nyckelord
- DNA methylation
- Illumina Human Methylation 450 BeadChip
- rectal cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Vymetalkova, Ver ...
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Vodicka, Pavel
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Pardini, Barbara
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Rosa, Fabio
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Levy, Miroslav
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Schneiderova, Mi ...
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visa fler...
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Liska, Vaclav
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Vodickova, Ludmi ...
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Nilsson, Torbjor ...
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Farkas, Sanja A. ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- LANTBRUKSVETENSKAPER
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LANTBRUKSVETENSK ...
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och Veterinärmedicin
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och Medicinsk biovet ...
- Artiklar i publikationen
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Epigenomics
- Av lärosätet
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Örebro universitet
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Umeå universitet