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Sökning: onr:"swepub:oai:DiVA.org:oru-52876" > Association of Peri...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005945naa a2200505 4500
001oai:DiVA.org:oru-52876
003SwePub
008161010s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:134589675
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-528762 URI
0247 a https://doi.org/10.1001/jamapsychiatry.2016.20952 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1345896752 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Brander, Gustafu Karolinska Institutet4 aut
2451 0a Association of Perinatal Risk Factors With Obsessive-Compulsive Disorder :b A Population-Based Birth Cohort, Sibling Control Study
264 1a Chicago, USA :b American Medical Association,c 2016
338 a print2 rdacarrier
500 a Funding Agencies:Karolinska InstitutetSwedish Research Council for Health, Working Life, and Welfare 2015-00075  2015-00569David and Astrid Hagelen Foundation
520 a Importance: Perinatal complications may increase the risk of obsessive-compulsive disorder (OCD). Previous reports were based on small, retrospective, specialist clinic-based studies that were unable to rigorously control for unmeasured environmental and genetic confounding.Objective: To prospectively investigate a wide range of potential perinatal risk factors for OCD, controlling for unmeasured factors shared between siblings in the analyses.Design, Setting, and Participants: This population-based birth cohort study included all 2 421 284 children from singleton births in Sweden from January 1, 1973, to December 31, 1996, who were followed up through December 31, 2013. From the 1 403 651 families in the cohort, differentially exposed siblings from the 743 885 families with siblings were evaluated; of these, 11 592 families included clusters of full siblings that were discordant for OCD. Analysis of the data was conducted from January, 26, 2015, to September, 5, 2016.Exposures: Perinatal data were collected from the Swedish Medical Birth Register and included maternal smoking during pregnancy, labor presentation, obstetric delivery, gestational age (for preterm birth), birth weight, birth weight in relation to gestational age, 5-minute Apgar score, and head circumference.Main Outcomes and Measures: Previously validated OCD codes (International Statistical Classification of Diseases and Health Related Problems, Tenth Revision, code F42) in the Swedish National Patient Register.Results: Of 2 421 284 individuals included in the cohort, 17 305 persons were diagnosed with OCD. Of these, 7111 were men (41.1%). The mean (SD) age of individuals at first diagnosis of OCD was 23.4 (6.5) years. An increased risk for OCD remained after controlling for shared familial confounders and measured covariates (including sex, year of birth, maternal and paternal age at birth, and parity), for smoking 10 or more cigarettes per day during pregnancy (hazard ratio [HR], 1.27; 95% CI, 1.02-1.58), breech presentation (HR, 1.35; 95% CI, 1.06-1.71), delivery by cesarean section (HR, 1.17; 95% CI, 1.01-1.34), preterm birth (HR, 1.24; 95% CI, 1.07-1.43), birth weight 1501 to 2500 g (HR, 1.30; 95% CI, 1.05-1.62) and 2501 to 3500 g (HR, 1.08; 95% CI, 1.01-1.16), being large for gestational age (HR, 1.23; 95% CI, 1.05-1.45), and Apgar distress scores at 5 minutes (HR, 1.50; 95% CI, 1.07-2.09). Gestational age and birth weight followed inverse dose-response associations, whereby an increasingly higher risk for OCD was noted in children with a shorter gestational age and lower birth weight. We also observed a dose-response association between the number of perinatal events and increased OCD risk, with HRs ranging from 1.11 (95% CI, 1.07-1.15) for 1 event to 1.51 (95% CI, 1.18-1.94) for 5 or more events.Conclusions and Relevance: A range of perinatal risk factors is associated with a higher risk for OCD independent of shared familial confounders, suggesting that perinatal risk factors may be in the causal pathway to OCD.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
653 a Psychiatry
653 a Psykiatri
7001 a Rydell, Minau Karolinska Institutet4 aut
7001 a Kuja-Halkola, Ralfu Karolinska Institutet4 aut
7001 a Fernández de la Cruz, Lorenau Karolinska Institutet4 aut
7001 a Lichtenstein, Paulu Karolinska Institutet4 aut
7001 a Serlachius, Evau Karolinska Institutet4 aut
7001 a Rück, Christianu Karolinska Institutet4 aut
7001 a Almqvist, Catarinau Karolinska Institutet4 aut
7001 a D'Onofrio, Brian M.u Karolinska Institutet4 aut
7001 a Larsson, Henrik,d 1975-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)hiln
7001 a Mataix-Cols, Davidu Karolinska Institutet4 aut
7102 a Karolinska Institutetb Institutionen för medicinska vetenskaper4 org
7730 t JAMA psychiatryd Chicago, USA : American Medical Associationg 73:11, s. 1135-1144q 73:11<1135-1144x 2168-6238x 2168-622X
8564 u https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2565603/yoi160058.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-52876
8564 8u https://doi.org/10.1001/jamapsychiatry.2016.2095
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134589675

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