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Adipose tissue conc...
Adipose tissue concentrations of persistent organic pollutants and the risk of prostate cancer
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Hardell, Lennart (författare)
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Andersson, Swen-Olof (författare)
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Carlberg, Michael (författare)
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Bohr, Louise (författare)
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- van Bavel, Bert (författare)
- Örebro universitet,Institutionen för naturvetenskap,MTM
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- Lindström, Gunilla (författare)
- Örebro universitet,Institutionen för naturvetenskap,MTM
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- Björnfoth, Helen (författare)
- Örebro universitet,Institutionen för naturvetenskap,MTM
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Ginman, Claes (författare)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2006
- 2006
- Engelska.
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Ingår i: Journal of Occupational and Environmental Medicine. - : Ovid Technologies (Wolters Kluwer Health). - 1076-2752 .- 1536-5948. ; 48:7, s. 700-707
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: We sought to study the concentrations of certain persistent organic pollutants with endocrine-disrupting properties in cases with prostate cancer and controls with benign prostate hyperplasia. METHODS: Adipose tissue was obtained from 58 cases and 20 controls. RESULTS: The median concentration among controls was used as cut-off in the statistical analysis. In the total material, a greater-than median concentration of PCB congener 153 yielded an odds ratio (OR) of 3.15 and 95% confidence interval (CI) of 1.04-9.54 and one chlordane type, trans-chlordane, yielded OR 3.49 (95% CI = 1.08-11.2). In the group of case subjects with PSA levels greater than the median level of 16.5 ng/mL, PCB 153 was OR 30.3 (95% CI = 3.24-284), hexachlorobenzene OR = 9.84 (95% CI = 1.99-48.5), trans-chlordane OR = 11.0 (95% CI = 1.87-64.9), and the chlordane-type MC6 OR = 7.58 (95% CI = 1.65-34.9). The grouping of PCBs according to structural and biological activity was found to produce significantly increased risks for enzyme and phenobarbital-inducing PCBs and lower chlorinated PCBs in the case group with PSA levels greater than 16.5 ng/mL. CONCLUSIONS: These chemicals might be of etiologic significance but need to be further investigated. The biological relevance of the arbitrary cut-off point of PSA is unclear.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- NATURAL SCIENCES
- NATURVETENSKAP
- Chemistry
- Kemi
- Environmental chemistry
- Miljökemi
- Chemistry
- Kemi
- Environmental Chemistry
- Miljökemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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