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An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015

Lucidarme, J. (författare)
Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
Scott, K. J. (författare)
Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom
Ure, R. (författare)
Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom
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Smith, A. (författare)
Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom; College of Medical, Veterinary & Life Sciences, Glasgow Dental Hospital & School, University of Glasgow, Glasgow, United Kingdom
Lindsay, D. (författare)
Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory, Glasgow Royal Infirmary, Glasgow, United Kingdom
Stenmark, Bianca, 1987- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
Jacobsson, Susanne, 1974- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
Fredlund, Hans, 1952- (författare)
Örebro universitet,Institutionen för hälsovetenskaper,National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden
Cameron, J. C. (författare)
Health Protection Scotland, NHS National Services Scotland, Glasgow, United Kingdom
Smith-Palmer, A. (författare)
Health Protection Scotland, NHS National Services Scotland, Glasgow, United Kingdom
McMenamin, J. (författare)
Health Protection Scotland, NHS National Services Scotland, Glasgow, United Kingdom
Gray, S. J. (författare)
Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
Campbell, H. (författare)
Immunisation Department, Public Health England, London, United Kingdom
Ladhani, S. (författare)
Immunisation Department, Public Health England, London, United Kingdom
Findlow, J. (författare)
Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
Mölling, Paula (författare)
National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Borrow, R. (författare)
Meningococcal Reference Unit, Public Health England, Manchester, United Kingdom
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 (creator_code:org_t)
Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC), 2016
2016
Engelska.
Ingår i: Eurosurveillance. - Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC). - 1025-496X .- 1560-7917. ; 21:45, s. 15-23
Relaterad länk:
https://doi.org/10.2...
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https://urn.kb.se/re...
https://doi.org/10.2...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The 23rd World Scout Jamboree in 2015 took place in Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases of laboratory-confirmed invasive serogroup W meningococcal disease occurred among scouts and their close contacts in Scotland and Sweden. The isolates responsible were identical to one-another by routine typing and, where known (4 isolates), belonged to the ST-11 clonal complex (cc11) which is associated with large outbreaks and high case fatality rates. Recent studies have demonstrated the need for high-resolution genomic typing schemes to assign serogroup W cc11 isolates to several distinct strains circulating globally over the past two decades. Here we used such schemes to confirm that the Jamboree-associated cases constituted a genuine outbreak and that this was due to a novel and rapidly expanding strain descended from the strain that has recently expanded in South America and the United Kingdom. We also identify the genetic differences that define the novel strain including four point mutations and three putative recombination events involving the horizontal exchange of 17, six and two genes, respectively. Noteworthy outcomes of these changes were antigenic shifts and the disruption of a transcriptional regulator.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

Infektionssjukdomar
Infectious Diseases

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