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Novel Chlorinated P...
Novel Chlorinated Polyfluorinated Ether Sulfonates and Legacy Per-/Polyfluoroalkyl Substances : Placental Transfer and Relationship with Serum Albumin and Glomerular Filtration Rate
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- Pan, Yitao (author)
- Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China
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- Zhu, Yingshuang (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China
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- Zheng, Tongzhang (author)
- Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island, United States
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- Cui, Qianqian (author)
- Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China
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- Buka, Stephen L. (author)
- Department of Epidemiology, School of Public Health, Brown University, Providence RI, United States
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- Zhang, Bin (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Women and Children Medical and Healthcare Center of Wuhan, Wuhan, P. R. China
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- Guo, Yong (author)
- Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, P. R. China
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- Xia, Wei (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China
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- Yeung, Leo W. Y., 1981- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM)
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- Li, Yuanyuan (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China
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- Zhou, Aifen (author)
- Women and Children Medical and Healthcare Center of Wuhan, Wuhan, P. R. China
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- Qiu, Lin (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Women and Children Medical and Healthcare Center of Wuhan, Wuhan, P. R. China
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- Liu, Hongxiu (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; Women and Children Medical and Healthcare Center of Wuhan, P. R. China
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- Jiang, Minmin (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China
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- Wu, Chuansha (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China
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- Xu, Shunqing (author)
- Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China
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- Dai, Jiayin (author)
- Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China
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Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P R. China Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China; State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China (creator_code:org_t)
- 2016-12-22
- 2017
- English.
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In: Environmental Science and Technology. - Dordrecht, Neteherlands : Springer Netherlands. - 0013-936X .- 1520-5851. ; 51:1, s. 634-644
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Per- and polyfluoroalkyl substances (PFASs) may cross the placental barrier and lead to fetal exposure. However, little is known about the factors that influence maternal-fetal transfer of these chemicals. PFAS concentrations were analyzed in 100 paired samples of human maternal sera collected in each trimester and cord sera at delivery; these samples were collected in Wuhan, China, 2014. Linear regression was used to estimate associations of transfer efficiencies with factors. Chlorinated polyfluorinated ether sulfonates (Cl-PFAESs, 6:2 and 8:2) were frequently detected (>99%) in maternal and cord sera. A significant decline in PFAS levels during the three trimesters was observed. A U-shape trend for transfer efficiency with increasing chain length was observed for both carboxylates and sulfonates. Higher transfer efficiencies of PFASs were associated with advancing maternal age, higher education, and lower glomerular filtration rate (GFR). Cord serum albumin was a positive factors for higher transfer efficiency (increased 1.1-4.1% per 1g/L albumin), whereas maternal serum albumin tended to reduce transfer efficiency (decreased 2.4-4.3% per 1g/L albumin). Our results suggest that exposure to Cl-PFAESs may be widespread in China. The transfer efficiencies among different PFASs were structure-dependent. Physiological factors (e.g., GFR and serum albumin) were observed for the first time to play critical roles in PFAS placental transfer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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- art (subject category)
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- By the author/editor
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Pan, Yitao
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Zhu, Yingshuang
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Zheng, Tongzhang
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Cui, Qianqian
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Buka, Stephen L.
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Zhang, Bin
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Guo, Yong
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Xia, Wei
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Yeung, Leo W. Y. ...
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Li, Yuanyuan
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Zhou, Aifen
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Qiu, Lin
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Liu, Hongxiu
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Jiang, Minmin
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Wu, Chuansha
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Xu, Shunqing
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Dai, Jiayin
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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Environmental Sc ...
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Örebro University