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Prognostic signific...
Prognostic significance of phospho-histone H3 in prostate carcinoma
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- Nowak, Michael (författare)
- Inst Pathol, Univ Hosp Bonn, Bonn, Germany.; Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany.
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- Svensson, Maria A. (författare)
- Region Örebro län,Dept Lab Med, Univ Hosp Örebro, Örebro, Sweden; Dept Urol, Univ Hosp Örebro, Örebro, Sweden; Inst Hlth & Med Sci, Univ Örebro, Örebro, Sweden
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- Carlsson, Jessica, 1984- (författare)
- Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Dept Urol, Örebro, Örebro University Hospital, Örebro, Sweden
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- Vogel, Wenzel (författare)
- Inst Pathol, Univ Hosp Bonn, Bonn, Germany; Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
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- Kebschull, Moritz (författare)
- Dept Periodontol Operat & Prevent Dent, Univ Bonn, Bonn, Germany
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- Wernert, Nicolas (författare)
- Inst Pathol, Univ Hosp Bonn, Bonn, Germany
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- Kristiansen, Glen (författare)
- Inst Pathol, Univ Hosp Bonn, Bonn, Germany
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- Andren, Ove, 1963- (författare)
- Region Örebro län,Örebro universitet, Institutionen för hälsovetenskap och medicin,Dept Urol, Örebro University Hospital, Örebro, Sweden
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- Braun, Martin (författare)
- Inst Pathol, Univ Hosp Bonn, Bonn, Germany.; Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
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- Perner, Sven (författare)
- Inst Pathol, Univ Hosp Bonn, Bonn, Germany.; Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany
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Region Örebro län Inst Pathol, Univ Hosp Bonn, Bonn, Germany; Dept Prostate Canc Res, Univ Hosp Bonn, Bonn, Germany. (creator_code:org_t)
- 2013-07-26
- 2014
- Engelska.
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Ingår i: World journal of urology. - : Springer-Verlag New York. - 0724-4983 .- 1433-8726. ; 32:3, s. 703-707
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Prostate cancer is the second most common cancer in men and the sixth most common cause of death from cancer in men worldwide. Currently, a sufficient pathological distinction between patients requiring further treatment and those for which active surveillance remains an option is still lacking, which leads to the problem of overtreatment. Cell proliferation is routinely assessed by detecting Ki-67 antigen. While Ki-67 is expressed throughout the interphase of proliferating cells, phosphorylation of the chromatin constituent histone H3 occurs only during the late G2 phase and mitosis thus providing a more strict assessment of the mitotic activity. We undertook this study to test whether expression of the recently introduced proliferation marker phospho-histone H3 (pHH3) in prostate carcinoma tissue sections exhibits prognostic significance in comparison with Ki-67. Protein expression of pHH3 and Ki-67 was assessed on TMA consisting of paraffin-embedded tissue from men that had undergone radical prostatectomy. The analysis included triplicate tissue cores of a total of 339 tumor foci. Immunohistochemical staining of pHH3 and Ki-67 was performed and analyzed using Definiens imaging software. Prostate cancer tissue exhibited a significantly higher frequency of pHH3-positive cells compared to benign prostate tissue. pHH3 expression was significantly correlated with Ki-67 expression. Furthermore, statistical analysis revealed positive correlation between pHH3 expression and PSA levels at diagnosis and in addition negatively correlated with overall survival. In contrast to Ki-67 staining, pHH3 expression did not correlate with Gleason grade. Our data point to a conceivable role of pHH3 as prognostic biomarker in prostate carcinoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Prostate cancer
- Phospho-histone H3
- Mitosis
- Prognostic marker
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Nowak, Michael
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Svensson, Maria ...
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Carlsson, Jessic ...
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Vogel, Wenzel
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Kebschull, Morit ...
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Wernert, Nicolas
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visa fler...
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Kristiansen, Gle ...
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Andren, Ove, 196 ...
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Braun, Martin
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Perner, Sven
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