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The Prevalence of C...
The Prevalence of Celiac Disease in the United States
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- Rubio-Tapia, Alberto (författare)
- Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester MN, United States
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet
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- Brantner, Tricia L. (författare)
- Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester MN, United States
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- Murray, Joseph A. (författare)
- Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester MN, United States
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- Everhart, James E. (författare)
- Department of Health and Human Services, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda MD, United States
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(creator_code:org_t)
- Nature Publishing Group, 2012
- 2012
- Engelska.
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Ingår i: American Journal of Gastroenterology. - : Nature Publishing Group. - 0002-9270 .- 1572-0241. ; 107:10, s. 1538-1544
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- OBJECTIVES: The prevalence of celiac disease (CD) in the United States is unknown. We sought to estimate CD prevalence nationwide by using a nationally representative sample.METHODS: This study included 7,798 persons aged 6 years or older who participated in the National Health and Nutrition Examination Survey 2009-2010. Serum samples from all participants were tested for immunoglobulin A (IgA) tissue transglutaminase antibodies and, if findings were abnormal, also for IgA endomysial antibodies. Information about prior diagnosis of CD and use of a gluten-free diet (GFD) was obtained by direct interview. CD was defined as having either double-positive serology (serologically diagnosed CD) or a reported diagnosis of CD by a doctor or other health-care professional and being on a GFD (reported clinical diagnosis of CD).RESULTS: CD was found in 35 participants, 29 of whom were unaware of their diagnosis. Median age was 45 years (interquartile range, 23-66 years); 20 were women and 29 were non-Hispanic white. The prevalence of CD in the United States was 0.71% (95% confidence interval (CI), 0.58-0.86%), with 1.01% (95% CI, 0.78-1.31%) among non-Hispanic whites. In all, 55 participants reported following a GFD, which corresponded to a prevalence of 0.63% (95% CI, 0.36-1.07%).CONCLUSIONS: The prevalence of CD in the United States was 0.71% (1 in 141), similar to that found in several European countries. However, most cases were undiagnosed. CD was rare among minority groups but affected 1% of non-Hispanic whites. Most persons who were following a GFD did not have a diagnosis of CD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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