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- Ludvigsson, Jonas F.,1969-Karolinska Institutet (författare)
Increased risk of epilepsy in biopsy-verified celiac disease : A population-based cohort study
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
- Lippincott Williams & Wilkins,2012
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-55811
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-55811URI
- https://doi.org/10.1212/WNL.0b013e3182544728DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:124549885URI
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- Språk:engelska
- Sammanfattning på:engelska
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Anmärkningar
- Funding Agencies:Sven Jerring FoundationÖrebro Society of MedicineKarolinska Institutet, Örebro University HospitalClas Groschinsky FoundationJuhlin FoundationMajblomman Foundation, Uppsala-Örebro Regional Research CouncilSwedish Celiac SocietyStockholm County CouncilEisaiGlaxoSmithKlineJohnson & Johnson/Janssen-Cilag NovartisSanofi-AventisPfizerUCB
- Objectives: Celiac disease (CD) is associated with several neurologic disorders but it is unclear whether CD is associated with epilepsy. We therefore investigated whether biopsy-verified CD is associated with epilepsy.Methods: Cohort study. Using biopsy report data from all Swedish pathology departments (n = 28), we identified individuals with CD who were diagnosed from 1969 to 2008 (Marsh 3: villous atrophy). Through Cox regression, we calculated hazard ratios (HRs) for epilepsy (defined as a diagnosis of epilepsy in the Swedish National Patient Register) in 28,885 individuals with CD and 143,166 controls matched for age, sex, calendar period, and county.Results: Individuals with CD were at an increased risk of future epilepsy (HR = 1.42; 95% confidence interval [CI] = 1.24-1.62) (272 individuals with CD had a diagnosis of epilepsy vs an expected 192). The absolute risk of future epilepsy in patients with CD was 92/100,000 person-years (excess risk = 27/100,000 person-years). This risk increase was seen in all ages, including children with CD. The HR for having at least 2 interactions with health care due to epilepsy was 1.41 (95% CI = 1.19-1.66). When we restricted epilepsy to those with both a diagnosis of epilepsy and an independent record of antiepileptic drug prescriptions, CD was associated with a 1.43-fold increased risk of epilepsy (95% CI = 1.10-1.86).Conclusion: Individuals with CD seem to be at a moderately increased risk of epilepsy. Neurology (R) 2012;78:1401-1407
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Neurologi
- Neurology
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Zingone, F.Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy (författare)
- Tomson, T.Karolinska Institutet (författare)
- Ekbom, A.Karolinska Institutet (författare)
- Ciacci, C.Department of Gastroenterology, University of Salerno, Salerno, Italy (författare)
- Karolinska InstitutetDepartment of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Neurology: Lippincott Williams & Wilkins78:18, s. 1401-14070028-38781526-632X
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