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Sökning: onr:"swepub:oai:DiVA.org:oru-56368" > Underdiagnosis of C...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006222naa a2200553 4500
001oai:DiVA.org:oru-56368
003SwePub
008170315s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-563682 URI
0247 a https://doi.org/10.1016/S1473-3099(14)70991-02 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Davies, Kerrie A.u EUCLID European Coordinators, Univ Leeds, Leeds, England4 aut
2451 0a Underdiagnosis of Clostridium difficile across Europe :b the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)
264 1b Elsevier,c 2014
338 a print2 rdacarrier
500 a Funding Agency:Astellas Pharmaceuticals Europe 
520 a Background: Variations in testing for Clostridium difficile infection can hinder patients' care, increase the risk of transmission, and skew epidemiological data. We aimed to measure the underdiagnosis of C difficile infection across Europe.Methods: We did a questionnaire-based study at 482 participating hospitals across 20 European countries. Hospitals were questioned about their methods and testing policy for C difficile infection during the periods September, 2011, to August, 2012, and September, 2012, to August, 2013. On one day in winter, 2012-13 (December, 2012, or January, 2013), and summer, 2013 (July or August), every hospital sent all diarrhoeal samples submitted to their microbiology laboratory to a national coordinating laboratory for standardised testing of C difficile infection. Our primary outcome measures were the rates of testing for and cases of C difficile infection per 10 000 patient bed-days. Results of local and national C difficile infection testing were compared with each other. If the result was positive at the national laboratory but negative at the local hospital, the result was classified as undiagnosed C difficile infection. We compared differences in proportions with the Mann-Whitney test, or McNemar's test if data were matched.Findings: During the study period, participating hospitals reported a mean of 65.8 tests (country range 4. 6-223.3) for C difficile infection per 10 000 patient-bed days and a mean of 7.0 cases (country range 0.7-28.7) of C difficile infection per 10 000 patient-bed days. Only two-fifths of hospitals reported using optimum methods for testing of C difficile infection (defined by European guidelines), although the number of participating hospitals using optimum methods increased during the study period, from 152 (32%) of 468 in 2011-12 to 205 (48%) of 428 in 2012-13. Across all 482 European hospitals on the two sampling days, 148 (23%) of 641 samples positive for C difficile infection (as determined by the national laboratory) were not diagnosed by participating hospitals because of an absence of clinical suspicion, equating to about 74 missed diagnoses per day.Interpretation: A wide variety of testing strategies for C difficile infection are used across Europe. Absence of clinical suspicion and suboptimum laboratory diagnostic methods mean that an estimated 40 000 inpatients with C difficile infection are potentially undiagnosed every year in 482 European hospitals.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Longshaw, Christopher M.u Astellas Pharma Europe, Chertsey, England4 aut
7001 a Davis, Georgina L.u EUCLID European Coordinators, Univ Leeds, Leeds, England4 aut
7001 a Bouza, Emiliou Microbiol Clin E Infecc, Catedral Jefe Serv, Gen Hosp, Univ Gregorio Maranon, Madrid, Spain4 aut
7001 a Barbut, Fredericu Natl Reference Lab Clostridium Difficile, Univ Paris 06, Paris, France4 aut
7001 a Barna, Zsuzsannau Dept Bacteriol, Natl Ctr Epidemiol, Budapest, Hungary4 aut
7001 a Delmee, Michelu Institute of Experimental and Clinical Research, Catholic Univ Louvain, Brussels, Belgium4 aut
7001 a Fitzpatrick, Fidelmau Hlth Protect Surveillance Ctr, Dublin, Ireland; Beaumont Hosp, Dublin, Ireland4 aut
7001 a Ivanova, Kateu Natl Ctr Infect & Parasit Dis, Sofia, Bulgaria4 aut
7001 a Kuijper, Edu Med Ctr, Dept Med Microbiol, Leiden Univ, Leiden, Netherlands4 aut
7001 a Macovei, Ioana S.u Cantacuzino Natl Inst Res & Dev Microbiol & Immun, Bucharest, Romania4 aut
7001 a Mentula, Siljau Bacteriol Unit, Natl Inst Hlth & Welf (THL), Helsinki, Finland4 aut
7001 a Mastrantonio, Paolau Dept Infect Dis, Ist Super Sanita, Rome, Italy4 aut
7001 a von Mueller, Lutzu Med Ctr, Inst Med Microbiol & Hyg, Univ Saarland, Homburg, Germany4 aut
7001 a Oleastro, Monicau Dept Infect Dis, Natl Inst Hlth Dr Ricardo Jorge, Lisbon, Portugal4 aut
7001 a Petinaki, Efthymiau Sch Med, Univ Hosp, Univ Thessalia, Larisa, Greece4 aut
7001 a Pituch, Hannau Dept Med Microbiol, Med Univ Warsaw, Warsaw, Poland4 aut
7001 a Norén, Torbjörn,d 1955-u Region Örebro län4 aut0 (Swepub:oru)trnn
7001 a Novakova, Elenau Jessenius Fac Med Martin, Comenius Univ, Martin, Slovakia4 aut
7001 a Nyc, Otakaru Dept Med Microbiol, Univ Hosp Motol, Prague, Czech Republic4 aut
7001 a Rupnik, Majau Fac Med, Univ Maribor, Maribor, Slovenia; Natl Lab Hlth Environm & Food (NLZOH), Maribor, Slovenia4 aut
7001 a Schmid, Danielau Inst Med Microbiol & Hyg, Austrian Agcy Hlth & Food Safety, Vienna,Austria.4 aut
7001 a Wilcox, Mark H.u EUCLID European Coordinators, Univ Leeds, Leeds, England4 aut
7102 a EUCLID European Coordinators, Univ Leeds, Leeds, Englandb Astellas Pharma Europe, Chertsey, England4 org
7730 t The Lancet - Infectious diseasesd : Elsevierg 14:12, s. 1208-1219q 14:12<1208-1219x 1473-3099x 1474-4457
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56368
8564 8u https://doi.org/10.1016/S1473-3099(14)70991-0

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