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AAI-guided anaesthe...
AAI-guided anaesthesia is associated with lower incidence of 24-h MMSE < 25 and may impact the IL-6 response
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- Jildenstål, Pether K., 1970- (författare)
- Region Örebro län,Department of Anaesthesiology and Intensive Care, Örebro University Hospital, Örebro, Sweden
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- Hallén, Jan L. (författare)
- Department of Anaesthesiology and Intensive Care, University Hospital, Örebro, Sweden
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- Rawal, Narinder, 1940- (författare)
- Department of Anaesthesiology and Intensive Care, University Hospital, Örebro, Sweden
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- Berggren, Lars, 1949- (författare)
- Region Örebro län,Department of Anaesthesiology and Intensive Care, Örebro University Hospital, Örebro, Sweden; Department of Anaesthesiology and Intensive Care, Institution for Clinical Science, Danderyds University Hospital, The Karolinska Institute, Stockholm, Sweden
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- Jakobsson, Jan G. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- Engelska.
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Ingår i: International Journal of Surgery. - : Elsevier. - 1743-9191 .- 1743-9159. ; 12:4, s. 290-295
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Trauma stress and neuro-inflammation caused by surgery/anaesthesia releases cytokines. This study analysed impact of Auditory Evoked Potential Index (AAI) depth-of-anaesthesia titration on the early plasma IL-6 release after eye surgery under general anaesthesia.Method: This is a subgroup analysis of a prospective randomized study on the effect of auditory evoked potential guided anaesthesia for eye surgery. Plasma IL-6 levels taken before, 5 and 24 h after end of surgery from 450 patients undergoing elective ophthalmic surgery under desflurane anaesthesia were analysed. Minimal mental state examination (MMSE) was also tested at 24-h.Results: IL-6 increased significantly at both 5 and further at 24 h after surgery (3.2, 4.5 and 5.1 base-line, 5 and 24-h respectively), the IL-6 increase showed different patterns between the 2 groups; IL-6 was significantly increased in the control group of patients between preoperative baseline and 24 h after surgery (p = 0.008) also between 5 h and 24 h, (p = 0.006) after surgery while the AAI-group had only minor non-significant changes. The 18 patients that showed a 24-h MMSE score less than 25 had a significant higher 24-h IL-6 compared to the 390 patients with a MMSE score > 24 (p = 0.002).Conclusion: The IL-6 increase after surgery was less pronounced in patients where anaesthesia was titrated by AAI compared to anaesthesia adjusted on clinical signs only. IL-6 were also found to be higher in patients with a MMSE < 25 at 24-h. Further studies are warranted evaluating the role of depth of anaesthesia monitoring on the risk for early cognitive impairment and neuro-inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Cognitive decline
- General anaesthesia
- Auditory evoked potential (AEP) monitoring
- Minor surgery
- IL-6
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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