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Risk of Dementia in...
Risk of Dementia in Patients with Celiac Disease : A Population-Based Cohort Study
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- Lebwohl, Benjamin (författare)
- Dept Med, Celiac Dis Ctr, Columbia Univ Coll Phys & Surg, New York NY, USA; Dept Med Epidemiol & Biostat, Karolinska Univ Hosp, Stockholm, Sweden; Karolinska Institute, Stockholm, Sweden; Dept Med, Columbia Univ Coll Phys & Surg, New York, NY, USA; Med Ctr, Mailman Sch Publ Hlth, Dept Epidemiol, Columbia Univ, New York NY, USA
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- Luchsinger, Jose A. (författare)
- Dept Med, Columbia Univ Coll Phys & Surg, New York NY, USA; Med Ctr, Mailman Sch Publ Hlth, Dept Epidemiol, Columbia Univ, New York NY, USA
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- Freedberg, Daniel E. (författare)
- Dept Med, Columbia Univ Coll Phys & Surg, New York NY, USA
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- Green, Peter H. R. (författare)
- Dept Med, Celiac Dis Ctr, Columbia Univ Coll Phys & Surg, New York NY, USA
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- Ludvigsson, Jonas F. (författare)
- Karolinska Institutet,Region Örebro län,Dept Med Epidemiol & Biostat, Karolinska Univ Hosp, Stockholm, Sweden; Karolinska Inst, Stockholm, Sweden; Dept Pediat, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 49:1, s. 179-185
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Patients with celiac disease (CD) frequently report cognitive symptoms when they are exposed to gluten, and cognitive deficits have been quantified in patients with newly diagnosed CD. Objective: To determine whether patients with CD have an increased risk of dementia. Methods: Using a population-based database of older adults (age >= 50 years) with histologically proven CD (duodenal/jejunal villous atrophy) from all 28 pathology departments in Sweden, we compared the incidence of a subsequent dementia diagnosis to those of age-and gender-matched controls. Results: Among patients with CD (n = 8,846) and controls (n = 43,474), the median age was 63 years and 56% were female. During a median follow-up time of 8.4 years, dementia was diagnosed in 4.3% of CD patients and 4.4% of controls (HR 1.07; 95% CI 0.95-1.20). Although there was an increased risk of dementia in the first year following a diagnosis of CD (HR 1.73; 95% CI 1.15-2.61), this risk was not present in the whole observation period. Among those subjects with a dementia subtype specified, the increased risk was restricted to vascular dementia (HR 1.28; 95% CI 1.00-1.64) and was not present for Alzheimer's dementia (HR 1.12; 95% CI 0.91-1.37). Conclusions: Patients with CD are not at increased risk for dementia overall, though subgroup analysis suggests that they may be at increased risk for vascular dementia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- celiac disease
- dementia
- epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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