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Antibiotic exposure...
Antibiotic exposure and the development of coeliac disease : a nationwide case-control study
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- Marild, Karl (författare)
- Karolinska Institutet
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- Ye, Weimin (författare)
- Karolinska Institutet
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- Lebwohl, Benjamin (författare)
- Columbia Univ Med Ctr, Celiac Dis Ctr, Dept Med, Columbia Univ, New York NY, USA
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- Green, Peter H. R. (författare)
- Columbia Univ Med Ctr, Celiac Dis Ctr, Dept Med, Columbia Univ, New York NY, USA
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- Blaser, Martin J. (författare)
- Dept Med, Langone Med Ctr, New York University, New York NY, USA
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- Card, Tim (författare)
- Div Epidemiol & Publ Hlth, City Hosp, Univ Nottingham, Nottingham, England.
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- Ludvigsson, Jonas F. (författare)
- Karolinska Institutet,Region Örebro län,Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden; Dept Paediat, Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- 2013
- 2013
- Engelska.
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Ingår i: BMC Gastroenterology. - 1471-230X. ; 13
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The intestinal microbiota has been proposed to play a pathogenic role in coeliac disease (CD). Although antibiotics are common environmental factors with a profound impact on intestinal microbiota, data on antibiotic use as a risk factor for subsequent CD development are scarce. Methods: In this population-based case-control study we linked nationwide histopathology data on 2,933 individuals with CD (Marsh stage 3; villous atrophy) to the Swedish Prescribed Drug Register to examine the association between use of systemic antibiotics and subsequent CD. We also examined the association between antibiotic use in 2,118 individuals with inflammation (Marsh 1-2) and in 620 individuals with normal mucosa (Marsh 0) but positive CD serology. All individuals undergoing biopsy were matched for age and sex with 28,262 controls from the population. Results: Antibiotic use was associated with CD (Odds ratio [OR] = 1.40; 95% confidence interval [CI] = 1.27-1.53), inflammation (OR = 1.90; 95% CI = 1.72-2.10) and normal mucosa with positive CD serology (OR = 1.58; 95% CI = 1.30-1.92). ORs for prior antibiotic use in CD were similar when we excluded antibiotic use in the last year (OR = 1.30; 95% CI = 1.08-1.56) or restricted to individuals without comorbidity (OR = 1.30; 95% CI = 1.16-1.46). Conclusions: The positive association between antibiotic use and subsequent CD but also with lesions that may represent early CD suggests that intestinal dysbiosis may play a role in the pathogenesis of CD. However, non-causal explanations for this positive association cannot be excluded.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Celiac
- Inflammation
- Microbiota
- Population-based case-control study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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