Sökning: onr:"swepub:oai:DiVA.org:oru-56722" >
Natural history of ...
-
Sorbe, Bengt,1947-Region Örebro län,Department of Oncology, Örebro University Hospital, Örebro, Sweden
(författare)
Natural history of recurrences in endometrial carcinoma
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
-
2014-07-18
-
Spandidos Publications,2014
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-56722
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56722URI
-
https://doi.org/10.3892/ol.2014.2362DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma (all FIGO stages). Overall, 90 tumors were of endometrioid type. A total of 82 patients were treated with surgery, 41 patients received adjuvant external irradiation and 91 patients received vaginal brachytherapy. The median time to recurrence (TTR) was 32 months. The recurrences were treated using a combination of high-dose-rate brachytherapy and external pelvic irradiation in 35 cases. In addition, 44 patients were treated with chemotherapy and 21 patients received other types of therapy. The complete remission rate was 29% and the overall response rate was 44%. Among patients treated with radiotherapy, the response rate was 88% and, for those treated with chemotherapy, the rate was 33%. The local control of vaginal recurrences treated with combined radiotherapy was 93%. In 45 patients (45%) a second recurrence was identified and a third recurrence occurred in 12 patients. The overall five-year survival rate was 44%. Age, FIGO grade, nuclear grade, TTR and response to treatment were found to be independent and significant prognostic factors for overall survival rate. Locoregional recurrences were associated with a generalized extra-pelvic disease in 63% of the cases.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Juresta, ChristianDepartment of Obstetrics and Gynecology, University Hospital, Örebro, Sweden
(författare)
-
Ahlin, CeciliaDepartment of Oncology, University Hospital, Örebro, Sweden
(författare)
-
Region Örebro länDepartment of Oncology, Örebro University Hospital, Örebro, Sweden
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Oncology Letters: Spandidos Publications8:4, s. 1800-18061792-10741792-1082
Internetlänk
Hitta via bibliotek
Till lärosätets databas