Sökning: onr:"swepub:oai:DiVA.org:oru-57317" >
Age but not Philade...
Age but not Philadelphia positivity impairs outcome in older/elderly patients with acute lymphoblastic leukemia in Sweden
-
- Kozlowski, Piotr, 1969- (författare)
- Örebro universitet,Institutionen för hälsovetenskaper,Örebro University, Sweden,Orebro Univ, Sch Med Sci, Dept Med, Orebro, Sweden.
-
- Lennmyr, Emma (författare)
- Uppsala universitet,Uppsala University,Hematologi
-
- Ahlberg, Lucia (författare)
- Linköpings universitet,Onkologi,Hälsouniversitetet,Region Östergötland, Hematologiska kliniken US,Linköping University Hospital,Univ Hosp Linkoping, Dept Hematol, Linkoping, Sweden.
-
visa fler...
-
- Bernell, Per (författare)
- Div of Hematology, Dept of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Karolinska Univ Hosp, Dept Med, Div Hematol, Stockholm, Sweden.
-
- Hulegårdh, Erik (författare)
- Dept of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg, Sweden,Sahlgrens Univ Hosp, Dept Hematol & Coagulat, Gothenburg, Sweden.
-
- Karbach, Holger (författare)
- Dept of Hematology, Cancer Center, University Hospital of Umeå, Umeå, Sweden,Norrland University Hospital,Univ Hosp Umea, Ctr Canc, Dept Hematol, Umea, Sweden.
-
- Karlsson, Karin (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skane Univ Hosp, Dept Hematol & Oncol, Lund, Sweden.
-
- Tomaszewska-Toporska, Beata (författare)
- Dept of Hematology and Oncology, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Hematol & Oncol, Lund, Sweden.
-
- Åström, Maria, 1959- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Örebro University, Sweden,Orebro Univ, Sch Med Sci, Dept Med, Orebro, Sweden.
-
- Hallböök, Helene (författare)
- Uppsala universitet,Uppsala University,Hematologi
-
The Swedish Adult Acute Lymphoblastic Leukemia Group (SVALL), Group author (författare)
-
visa färre...
-
(creator_code:org_t)
- 2017-06-14
- 2017
- Engelska.
-
Ingår i: European Journal of Haematology. - : Wiley-Blackwell Publishing Inc.. - 0902-4441 .- 1600-0609. ; 99:2, s. 141-149
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://onlinelibrar...
-
https://liu.diva-por... (primary) (Raw object)
-
http://dx.doi.org/10...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVES: Older/elderly patients with acute lymphoblastic leukemia (ALL) are poorly represented in clinical trials.METHODS: Using Swedish national leukemia registries, we investigated disease/patient characteristics, treatment choices, outcome, and the impact of an age-adapted protocol (introduced in 2009) in this population-based study of patients aged 55-85 years, diagnosed with ALL 2005-2012.RESULTS: Of 174 patients, 82% had B-phenotype, 11% Burkitt leukemia (excluded), and 7% T-phenotype. Philadelphia chromosome positivity (Ph+) occurred in 35%. Of the 155 B- and T- ALL patients, 80% were treated with intensive protocols, and 20% with a palliative approach. Higher age and WHO performance status ≥2 influenced the choice of palliation. Intensive, palliative, and both approaches, resulted in complete remission rate 83/16/70%, and 3 year overall survival (OS) 32/3/26%. The age-adapted protocol did not improve outcome. With intensive treatment, platelet count ≤35 × 10(9) /L, and age ≥75 years were adverse prognostic factors for OS, Ph+ was not. Male sex was an adverse prognostic factor in the 55-64 year group.CONCLUSIONS: We report a high frequency of Ph+ in older/elderly patients, with no evidence of poorer outcome compared to Ph negative disease. Overall prognosis for elderly patients with ALL remains dismal, despite the use of age-adapted treatment. This article is protected by copyright. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- acute lymphoblastic leukemia
- chemotherapy
- elderly
- epidemiology
- acute lymphoblastic leukemia
- chemotherapy
- elderly
- epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kozlowski, Piotr ...
-
Lennmyr, Emma
-
Ahlberg, Lucia
-
Bernell, Per
-
Hulegårdh, Erik
-
Karbach, Holger
-
visa fler...
-
Karlsson, Karin
-
Tomaszewska-Topo ...
-
Åström, Maria, 1 ...
-
Hallböök, Helene
-
The Swedish Adul ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
European Journal ...
- Av lärosätet
-
Örebro universitet
-
Linköpings universitet
-
Lunds universitet
-
Karolinska Institutet
-
Uppsala universitet