Sökning: onr:"swepub:oai:DiVA.org:oru-58707" >
Proinsulin, GLP-1, ...
Proinsulin, GLP-1, and glucagon are associated with partial remission in children and adolescents with newly diagnosed type 1 diabetes
-
- Kaas, Anne (författare)
- Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark
-
- Andersen, Marie Louise Max (författare)
- Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark
-
- Fredheim, Siri (författare)
- Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark
-
visa fler...
-
- Hougaard, Philip (författare)
- Department of Statistics, University of Southern Denmark, Odense, Denmark
-
- Buschard, Karsten (författare)
- Bartholin Institute, Rigshospitalet, Copenhagen, Denmark
-
- Petersen, Jacob Steen (författare)
- Diabetes Biology and Pharmacology, Novo Nordisk A/S, Måløv, Denmark
-
- de Beaufort, Carine (författare)
- Clinique Pédiatrique, Centre Hospitalier de Luxembourg, Luxembourg
-
- Robertson, Kenneth J. (författare)
- Department of Paediatrics, Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, United Kingdom
-
- Hansen, Lars (författare)
- Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark
-
- Mortensen, Henrik B. (författare)
- Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark
-
- Nielsen, Lotte B. (författare)
- Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark
-
- Åman, Jan, 1948- (bidragsgivare)
- Region Örebro län,Department of Paediatrics, Örebro University Hospital, Örebro, Sweden
-
visa färre...
-
(creator_code:org_t)
- 2011-11-27
- 2012
- Engelska.
-
Ingår i: Pediatric Diabetes. - : Wiley-Blackwell. - 1399-543X .- 1399-5448. ; 13:1, s. 51-58
- Relaterad länk:
-
https://orbilu.uni.l...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: Proinsulin is a marker of beta-cell distress and dysfunction in type 2 diabetes and transplanted islets. Proinsulin levels are elevated in patients newly diagnosed with type 1 diabetes. Our aim was to assess the relationship between proinsulin, insulin dose-adjusted haemoglobin A1c (IDAA1C), glucagon-like peptide-1 (GLP-1), glucagon, and remission status the first year after diagnosis of type 1 diabetes.Methods: Juvenile patients (n = 275) were followed 1, 6, and 12 months after diagnosis. At each visit, partial remission was defined as IDAA1C = 9%. The patients had a liquid meal test at the 1-, 6-, and 12-month visits, which included measurement of C-peptide, proinsulin, GLP-1, glucagon, and insulin antibodies (IA).Results: Patients in remission at 6 and 12 months had significantly higher levels of proinsulin compared to non-remitting patients (p < 0.0001, p = 0.0002). An inverse association between proinsulin and IDAA1C was found at 1 and 6 months (p = 0.0008, p = 0.0022). Proinsulin was positively associated with C-peptide (p < 0.0001) and IA (p = 0.0024, p = 0.0068, p < 0.0001) at 1, 6, and 12 months. Glucagon (p < 0.0001 and p < 0.02) as well as GLP-1 (p = 0.0001 and p = 0.002) were significantly lower in remitters than in non-remitters at 6 and 12 months. Proinsulin associated positively with GLP-1 at 1 month (p = 0.004) and negatively at 6 (p = 0.002) and 12 months (p = 0.0002).Conclusions: In type 1 diabetes, patients in partial remission have higher levels of proinsulin together with lower levels of GLP-1 and glucagon compared to patients not in remission. In new onset type 1 diabetes proinsulin level may be a sign of better residual beta-cell function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- GLP-1
- glucagon
- proinsulin
- type 1 diabetes
- remission phase
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kaas, Anne
-
Andersen, Marie ...
-
Fredheim, Siri
-
Hougaard, Philip
-
Buschard, Karste ...
-
Petersen, Jacob ...
-
visa fler...
-
de Beaufort, Car ...
-
Robertson, Kenne ...
-
Hansen, Lars
-
Mortensen, Henri ...
-
Nielsen, Lotte B ...
-
Åman, Jan, 1948-
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
- Artiklar i publikationen
-
Pediatric Diabet ...
- Av lärosätet
-
Örebro universitet