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Dual action of bact...
Dual action of bacteriocin PLNC8 alpha beta through inhibition of Porphyromonas gingivalis infection and promotion of cell proliferation
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- Bengtsson, Torbjörn, 1955- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University, Sweden
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- Zhang, Boxi (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Selegård, Robert, 1981- (författare)
- Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Molecular Physics, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, Sweden,Molekylär fysik,Tekniska fakulteten,Örebro University, Sweden
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- Wiman, Emanuel (författare)
- School of Medical Sciences, Örebro University, Örebro, Sweden
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- Aili, Daniel (författare)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
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- Khalaf, Hazem, 1981- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University, Sweden
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(creator_code:org_t)
- 2017-06-12
- 2017
- Engelska.
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Ingår i: Pathogens and Disease. - : Oxford University Press. - 2049-632X. ; 75:5
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Periodontitis is a chronic inflammatory disease that is characterised by accumulation of pathogenic bacteria, including Porphyromonas gingivalis, in periodontal pockets. The lack of effective treatments has emphasised in an intense search for alternative methods to prevent bacterial colonisation and disease progression. Bacteriocins are bacterially produced antimicrobial peptides gaining increased consideration as alternatives to traditional antibiotics. We show rapid permeabilisation and aggregation of P. gingivalis by the two-peptide bacteriocin PLNC8 alpha beta. In a cell culture model, P. gingivalis was cytotoxic against gingival fibroblasts. The proteome profile of fibroblasts is severely affected by P. gingivalis, including induction of the ubiquitin-proteasome pathway. PLNC8 alpha beta enhanced the expression of growth factors and promoted cell proliferation, and suppressed proteins associated with apoptosis. PLNC8 alpha beta efficiently counteracted P. gingivalis-mediated cytotoxicity, increased expression of a large number of proteins and restored the levels of inflammatory mediators. In conclusion, we show that bacteriocin PLNC8 alpha beta displays dual effects by acting as a potent antimicrobial agent killing P. gingivalis and as a stimulatory factor promoting cell proliferation. We suggest preventive and therapeutical applications of PLNC8 alpha beta in periodontitis to supplement the host immune defence against P. gingivalis infection and support wound healing processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Porphyromonas gingivalis
- periodontitis
- cell proliferation
- proteomics
- bacteriocin
- PLNC8
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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