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Sökning: onr:"swepub:oai:DiVA.org:oru-59356" > Prediction of non-a...

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

Orešič, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland
Kotronen, Anna (författare)
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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Gopalacharyulu, Peddinti (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Nygren, Heli (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Arola, Johanna (författare)
Department of Pathology, HUSLAB, University of Helsinki, Helsinki, Finland
Castillo, Sandra (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Mattila, Ismo (författare)
VTT Technical Research Centre of Finland, Espoo, Finland
Hakkarainen, Antti (författare)
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
Borra, Ronald J H (författare)
Turku PET Centre, University of Turku, Turku, Finland; Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
Honka, Miikka-Juhani (författare)
Turku PET Centre, University of Turku, Turku, Finland
Verrijken, An (författare)
Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
Francque, Sven (författare)
Department of Gastroenterology and Hepatology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium
Iozzo, Patricia (författare)
Turku PET Centre, University of Turku, Turku, Finland; Institute of Clinical Physiology, National Research Council, Pisa, Italy
Leivonen, Marja (författare)
Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
Jaser, Nabil (författare)
Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
Juuti, Anne (författare)
Department of Surgery, Helsinki University Central Hospital, Vantaa, Finland
Sørensen, Thorkild I A (författare)
Institute of Preventive Medicine, Copenhagen University Hospitals, Copenhagen, Denmark
Nuutila, Pirjo (författare)
Turku PET Centre, University of Turku, Turku, Finland
Van Gaal, Luc (författare)
Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
Yki-Järvinen, Hannele (författare)
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
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 (creator_code:org_t)
2013-07-04
2013
Engelska.
Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 56:10, s. 2266-2274
Relaterad länk:
https://doi.org/10.1...
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https://europepmc.or...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • AIMS/HYPOTHESIS: We examined whether analysis of lipids by ultra-performance liquid chromatography (UPLC) coupled to MS allows the development of a laboratory test for non-alcoholic fatty-liver disease (NAFLD), and how a lipid-profile biomarker compares with the prediction of NAFLD and liver-fat content based on routinely available clinical and laboratory data.METHODS: We analysed the concentrations of molecular lipids by UPLC-MS in blood samples of 679 well-characterised individuals in whom liver-fat content was measured using proton magnetic resonance spectroscopy ((1)H-MRS) or liver biopsy. The participants were divided into biomarker-discovery (n = 287) and validation (n = 392) groups to build and validate the diagnostic models, respectively.RESULTS: Individuals with NAFLD had increased triacylglycerols with low carbon number and double-bond content while lysophosphatidylcholines and ether phospholipids were diminished in those with NAFLD. A serum-lipid signature comprising three molecular lipids ('lipid triplet') was developed to estimate the percentage of liver fat. It had a sensitivity of 69.1% and specificity of 73.8% when applied for diagnosis of NAFLD in the validation series. The usefulness of the lipid triplet was demonstrated in a weight-loss intervention study.CONCLUSIONS/INTERPRETATION: The liver-fat-biomarker signature based on molecular lipids may provide a non-invasive tool to diagnose NAFLD, in addition to highlighting lipid molecular pathways involved in the disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Lipidomics; Mass spectrometry; Non-alcoholic fatty-liver disease

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