Sökning: onr:"swepub:oai:DiVA.org:oru-59387" >
Longitudinal plasma...
-
Jørgenrud, BenedicteDepartment of Pediatric Research, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway; Hormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
(författare)
Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
-
2016-01-21
-
Wiley-Blackwell Publishing Inc.2017
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-59387
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59387URI
-
https://doi.org/10.1111/pedi.12360DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agency:Research Council of Norway 214191 166515/V50
-
AIMS: The aim of this study was to investigate the longitudinal plasma metabolic profiles in healthy infants and the potential association with breastfeeding duration and islet autoantibodies predictive of type 1 diabetes.METHOD: Up to four longitudinal plasma samples from age 3 months from case children who developed islet autoimmunity (n = 29) and autoantibody-negative control children (n = 29) with the HLA DR4-DQ8/DR3-DQ2 genotype were analyzed using two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer for detection of small polar metabolites.RESULTS: Plasma metabolite levels were found to depend strongly on age, with fold changes varying up to 50% from age 3 to 24 months (p < 0.001 after correction for multiple testing). Tyrosine levels tended to be lower in case children, but this was not significant after correction for multiple testing. Ornithine levels were lower in case children compared with the controls at the time of seroconversion, but the difference was not statistically significant after correcting for multiple testing. Breastfeeding for at least 3 months as compared with shorter duration was associated with higher plasma levels of isoleucine, and lower levels of methionine and 3,4-dihydroxybutyric acid at 3 months of age.CONCLUSIONS: Plasma levels of several small, polar metabolites changed with age during early childhood, independent of later islet autoimmunity status and sex. Breastfeeding was associated with higher levels of branched-chain amino acids, and lower levels of methionine and 3,4-dihydroxybutyric acid.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Stene, Lars CDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
(författare)
-
Tapia, GermanDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
(författare)
-
Bøås, HåkonDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
(författare)
-
Pepaj, MilaimHormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
(författare)
-
Berg, Jens PDivision of Diagnostic and Intervention, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
(författare)
-
Thorsby, Per MHormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
(författare)
-
Orešič, Matej,1967-Systems Medicine Department, Steno Diabetes Centre, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc
(författare)
-
Hyötyläinen, Tuulia,1971-Systems Medicine Department, Steno Diabetes Centre, Gentofte, Denmark; VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)tihn
(författare)
-
Rønningen, Kjersti SDepartment of Pediatric Research, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway
(författare)
-
Department of Pediatric Research, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway; Hormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, NorwayDivision of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Pediatric Diabetes: Wiley-Blackwell Publishing Inc.18:2, s. 111-1191399-543X1399-5448
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jørgenrud, Bened ...
-
Stene, Lars C
-
Tapia, German
-
Bøås, Håkon
-
Pepaj, Milaim
-
Berg, Jens P
-
visa fler...
-
Thorsby, Per M
-
Orešič, Matej, 1 ...
-
Hyötyläinen, Tuu ...
-
Rønningen, Kjers ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
- Artiklar i publikationen
-
Pediatric Diabet ...
- Av lärosätet
-
Örebro universitet