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Survival and progno...
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Skírnisdóttir, IngirídurUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson
(författare)
Survival and prognostic factors in early-stage epithelial ovarian carcinoma treated with taxane-based adjuvant chemotherapy
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-10-01
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Cambridge, Mass.Blackwell,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-6058
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-6058URI
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https://doi.org/10.1111/j.1525-1438.2007.00928.xDOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14210URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The present study was undertaken with the question about the outcome (recurrence-free survival, [RFS]) after adjuvant chemotherapy with taxane and carboplatin in the early stages of epithelial ovarian cancer after primary surgery. Treatment-related toxicity was also evaluated. A total of 113 patients were included in this study. The 5-year RFS rate for all 113 patients treated with adjuvant chemotherapy including taxane and carboplatin after primary surgery was 79%. The 5-year RFS rate for 85 patients in FIGO stage I was 85% and for 18 patients in FIGO stage II, it was 44%. For clear-cell carcinomas, the RFS was 87%. In univariate analysis, recurrent disease was associated with both FIGO stage and tumor grade, but in multivariate logistic regression analysis of prognostic factors for tumor recurrences, only FIGO stage (stage I versus stage II) was a significant and independent prognostic factor. However, an odds ratio (OR) of 1.9 for tumor grade (grade 3 versus grades 1–2) demonstrated two times increased risk for recurrence in a patient with a grade 3 tumor compared with grade 1–2 tumors. Furthermore, an OR of 0.39 for lymph node sampling versus no sampling meant 61% reduced risk for recurrence for a patient who had undergone lymph node sampling at surgical staging laparotomy. The major toxicities in the present study were myelosuppression (46%) and neurotoxicity (34%). Despite the use of prophylaxis, severe paclitaxel-related hypersensitivity occurred in three patients (3%).
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sorbe, Bengt,1947-Örebro universitet,Hälsoakademin(Swepub:oru)bse
(författare)
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Uppsala universitetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Gynecological CancerCambridge, Mass. : Blackwell17:6, s. 1231-12371048-891X1525-1438
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