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Neisseria gonorrhoe...
Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance : a Novel Antimicrobial Resistance Multilocus Typing Scheme for Tracking Global Dissemination of N. gonorrhoeae Strains
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- Demczuk, Walter H.B. (författare)
- National Microbiology Laboratory, Winnipeg, Canada
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- Sidhu, S. (författare)
- National Microbiology Laboratory, Winnipeg, Canada
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- Unemo, Magnus, 1970- (författare)
- WHO Collaborating Centre for Gonorrhoea and Other STIs, Örebro University Hospital, Örebro, Sweden; School of Medical Sciences, Örebro University, Örebro, Sweden
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- Whiley, David M. (författare)
- Centre for Clinical Research, The University of Queensland, Brisbane, Australia
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- Allen, Vanessa G. (författare)
- Public Health Ontario Laboratories, Toronto , Canada
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- Dillon, Jeremiah R. (författare)
- Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
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- Cole, Michelle J. (författare)
- Public Health England, London, United Kingdom
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- Seah, Christine (författare)
- Public Health Ontario Laboratories, Toronto, Canada
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- Trembizki, Ella (författare)
- Centre for Clinical Research, The University of Queensland, Brisbane, Australia
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- Trees, David L. (författare)
- Centers for Disease Control and Prevention, Atlanta GA, United States
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- Kersh, Ellen N. (författare)
- Centers for Disease Control and Prevention, Atlanta GA, United States
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- Abrams, A. Jeanine (författare)
- Centers for Disease Control and Prevention, Atlanta GA, United States
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- de Vries, Henry J.C. (författare)
- STI Outpatient Clinic, Department of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, the Netherlands; Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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- van Dam, Alje P. (författare)
- Public Health Laboratory, Public Health Service Amsterdam, Amsterdam, the Netherlands; Department of Medical Microbiology, OLVG General Hospital, Amsterdam, the Netherlands;
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- Medina, I. (författare)
- National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg MB, Canada
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- Bharat, Amrita (författare)
- National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg MB, Canada
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- Mulvey, Michael Richard (författare)
- National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg MB, Canada
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- Van Domselaar, Gary (författare)
- National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg MB, Canada
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- Martin, Irene E. (författare)
- National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg MB, Canada
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(creator_code:org_t)
- American Society for Microbiology, 2017
- 2017
- Engelska.
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Ingår i: Journal of Clinical Microbiology. - : American Society for Microbiology. - 0095-1137 .- 1098-660X. ; 55:5, s. 1454-1468
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A curated Web-based user-friendly sequence typing tool based on antimicrobial resistance determinants in Neisseria gonorrhoeae was developed and is publicly accessible (https://ngstar.canada.ca). The N. gonorrhoeae Sequence Typing for Antimicrobial Resistance (NG-STAR) molecular typing scheme uses the DNA sequences of 7 genes (penA, mtrR, porB, ponA, gyrA, parC, and 23S rRNA) associated with resistance to β-lactam antimicrobials, macrolides, or fluoroquinolones. NG-STAR uses the entire penA sequence, combining the historical nomenclature for penA types I to XXXVIII with novel nucleotide sequence designations; the full mtrR sequence and a portion of its promoter region; portions of ponA, porB, gyrA, and parC; and 23S rRNA sequences. NG-STAR grouped 768 isolates into 139 sequence types (STs) (n = 660) consisting of 29 clonal complexes (CCs) having a maximum of a single-locus variation, and 76 NG-STAR STs (n = 109) were identified as unrelated singletons. NG-STAR had a high Simpson's diversity index value of 96.5% (95% confidence interval [CI] = 0.959 to 0.969). The most common STs were NG-STAR ST-90 (n = 100; 13.0%), ST-42 and ST-91 (n = 45; 5.9%), ST-64 (n = 44; 5.72%), and ST-139 (n = 42; 5.5%). Decreased susceptibility to azithromycin was associated with NG-STAR ST-58, ST-61, ST-64, ST-79, ST-91, and ST-139 (n = 156; 92.3%); decreased susceptibility to cephalosporins was associated with NG-STAR ST-90, ST-91, and ST-97 (n = 162; 94.2%); and ciprofloxacin resistance was associated with NG-STAR ST-26, ST-90, ST-91, ST-97, ST-150, and ST-158 (n = 196; 98.0%). All isolates of NG-STAR ST-42, ST-43, ST-63, ST-81, and ST-160 (n = 106) were susceptible to all four antimicrobials. The standardization of nomenclature associated with antimicrobial resistance determinants through an internationally available database will facilitate the monitoring of the global dissemination of antimicrobial-resistant N. gonorrhoeae strains.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- Neisseria gonorrhoeae
- antimicrobial resistance
- molecular epidemiology
- sequence typing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Demczuk, Walter ...
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Sidhu, S.
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Unemo, Magnus, 1 ...
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Whiley, David M.
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Allen, Vanessa G ...
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Dillon, Jeremiah ...
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visa fler...
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Cole, Michelle J ...
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Seah, Christine
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Trembizki, Ella
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Trees, David L.
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Kersh, Ellen N.
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Abrams, A. Jeani ...
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de Vries, Henry ...
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van Dam, Alje P.
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Medina, I.
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Bharat, Amrita
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Mulvey, Michael ...
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Van Domselaar, G ...
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Martin, Irene E.
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
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Journal of Clini ...
- Av lärosätet
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Örebro universitet