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Visualization of sp...
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Memedi, Mevludin,1983-Högskolan Dalarna,Datateknik
(författare)
Visualization of spirography-based objective measures in Parkinson's disease
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-06-06
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Wiley-Blackwell,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-62599
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-62599URI
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https://doi.org/10.1002/mds.25914DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-40474URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-14179URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:bth-23916URI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:vet swepub-contenttype
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Ämneskategori:kon swepub-publicationtype
Serie
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Movement Disorders,0885-31851531-8257
Anmärkningar
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Objective: To investigate whether advanced visualizations of spirography-based objective measures are useful in differentiating motor complications among Parkinson’s disease (PD) patients.Background: Sixty-five patients diagnosed with advanced PD have utilized a telemetry test battery, implemented on a touch screen handheld computer, in a telemedicine setting. On each test occasion, they were asked to perform repeated and time-stamped assessments of spiral drawing performance by tracing a pre-drawn Archimedes spiral. The test battery was also used by 10 healthy elderly (HE) subjects.Methods: A web-based framework was developed to visualize the performance during spirography of both patients and HE subjects to a clinician (DN). The performance was depicted by animating the spiral drawings (Fig 1). In addition, the framework displayed two time series views for representing drawing speed (blue line) and displacement from the ideal trajectory (orange line). The views are coordinated and linked i.e. user interactions in one of the views will be reflected in other views. For instance, when the user points in one of the pixels in spiral view, the circle size of the underlying pixel increases and a vertical line appears in the time series views to depict the corresponding position. Fig 1 shows single randomly selected spirals per each subject group: A) a PD patient in Dyskinesia state, B) a HE subject, and C) a PD patient in Off state.Results: The clinician recognized Dyskinesia symptoms as movements made with high speed, smooth/gradual spatial displacements, and a small amount of hesitation (Fig 1A). Similarly, Off symptoms were associated with low speed, sharp/abrupt spatial displacements, and a large amount of hesitation (Fig 1C). In contrast, the spiral drawn by a HE subject (Fig 1B) was associated with unchanging levels of kinematic features i.e. drawing speed, spatial displacements and hesitation over time.Conclusions: Visualizing spirography-based objective measures enables identification of trends and patterns of motor dysfunctions at the patient’s individual level. Dynamic access of visualized motor tests may be useful during the evaluation of therapy-related complications such as under- and over-medications. This will assist during individualized optimization of therapies, enabling patients to spend more time in the On state with a minimum of Off and dyskinetic states.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jusufi, IlirComputer Science, University of California, Davis, USA,Linneuniversitetet(Swepub:bth)iju
(författare)
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Nyholm, DagNeuroscience, Neurology, Uppsala University, Uppsala, Sweden
(författare)
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Högskolan DalarnaDatateknik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Movement Disorders Supplement: Wiley-Blackwell, s. S187-S1890885-3185
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