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Which measuring sit...
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Deminger, Anna,1973Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
(författare)
Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline : results from a 5-year prospective study
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-12-08
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London, United,Kingdom :BioMed Central,2017
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-63297
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63297URI
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https://doi.org/10.1186/s13075-017-1480-0DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143522URI
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https://gup.ub.gu.se/publication/260764URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies:Health and Medical Care Executive Board of the Västra Götaland Rune and Ulla Amlovs foundation for Rheumatology Research Göteborg's Association Against Rheumatism Swedish Association Against Rheumatism Medical Society of Göteborg Region Västra Götaland Controlling Chronic Inflammatory Diseases with Combined Efforts (COMBINE) Margareta Rheuma research foundation
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BACKGROUND: Studies have shown increased prevalence of osteoporosis and increased risk for vertebral fractures in patients with ankylosing spondylitis (AS). Measurements of bone mineral density (BMD) in the lumbar spine anterior-posterior (AP) projection may be difficult to interpret due to the ligamentous calcifications, and the lateral projection might be a better measuring site. Our objectives were to investigate BMD changes after 5 years at different measuring sites in patients with AS and to evaluate disease-related variables and medications as predictors for BMD changes.METHODS: In a longitudinal study, BMD in Swedish AS patients, 50 ± 13 years old, was measured with dual-energy x-ray absorptiometry (DXA) at the hip, the lumbar spine AP and lateral projections, and the total radius at baseline and after 5 years. Patients were assessed with questionnaires, blood samples, and spinal radiographs for grading of AS-related alterations in the spine with the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) and assessment of vertebral fractures by the Genant score. Multiple linear regression analyses were used to investigate predictors for BMD changes.RESULTS: Of 204 patients included at baseline, 168 (82%) were re-examined after 5 years (92 men and 76 women). BMD decreased significantly at the femoral neck and radius and increased significantly at the lumbar spine, both for AP and lateral projections. Mean C-reactive protein during follow-up predicted a decrease in the femoral neck BMD (change in %, β = -0.15, p = 0.046). Use of bisphosphonates predicted an increase in BMD at all measuring sites (p < 0.001 to 0.013), except for the total radius. Use of tumor necrosis factor inhibitors (TNFi) predicted an increase in AP spinal BMD (β = 3.15, p = 0.012).CONCLUSION: The current study (which has a long follow-up, many measuring sites, and is the first to longitudinally assess the lateral projection of the spine in AS patients) surprisingly showed that lateral projection spinal BMD increased. This study suggests that the best site to assess bone loss in AS patients is the femoral neck and that inflammation has an adverse effect, and the use of bisphosphonates and TNFi has a positive effect, on BMD in AS patients.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Klingberg, EvaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xkliev
(författare)
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Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xlomat
(författare)
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Geijer, Mats,1957-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Radiology, Örebro University Hospital, Örebro, Sweden; Department of Clinical Sciences, Lund University, Lund, Sweden(Swepub:gu)xgeima
(författare)
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Göthlin, JanDepartment of Radiology, Sahlgrenska University Hospital, Mölndal, Sweden(Swepub:gu)xgotja
(författare)
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Hedberg, MartinSection of Rheumatology, Södra Älvsborg Hospital, Borås, Sweden
(författare)
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Rehnberg, EvaSection of Rheumatology, Alingsås Hospital, Alingsås, Sweden
(författare)
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Carlsten, Hans,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xcahan
(författare)
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Jacobsson, Lennart T. H.,1954Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xjacle
(författare)
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Forsblad-d'Elia, HelenaGothenburg University,Göteborgs universitet,Umeå universitet,Reumatologi,Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xforhe
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Arthritis Research & TherapyLondon, United,Kingdom : BioMed Central191478-6362
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Deminger, Anna, ...
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Klingberg, Eva
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Lorentzon, Matti ...
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Geijer, Mats, 19 ...
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Göthlin, Jan
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Hedberg, Martin
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Rehnberg, Eva
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Carlsten, Hans, ...
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Jacobsson, Lenna ...
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Forsblad-d'Elia, ...
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