Sökning: onr:"swepub:oai:DiVA.org:oru-63632" >
Genome-wide profili...
-
Elo, Laura L.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
-
Cell Press,2010
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:oru-63632
-
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63632URI
-
https://doi.org/10.1016/j.immuni.2010.06.011DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding agencies:European Commission EC-FP7-SYBILLA-201106 EC-FP7-NANOMMUNE-214281 EC-FP7-DIABIMMUNE-202063 CIMO/SitraSigrid Juselius FoundationDepartment of Biotechnology, Government of IndiaTurku University HospitalNote: The Turku Centre for Biotechnology is a joint department of the Turku University and the Åbo Akademi University
-
Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Järvenpää, HennaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(författare)
-
Tuomela, SoileTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(författare)
-
Raghav, SunilTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
-
Ahlfors, HelenaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland
(författare)
-
Laurila, KirstiDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland
(författare)
-
Gupta, BhawnaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
-
Lund, Riikka J.Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom
(författare)
-
Tahvanainen, JohannaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland
(författare)
-
Hawkins, R. DavidLudwig Institute for Cancer Research, University of California, San Diego CA, United States
(författare)
-
Oresic, Matej,1967-VTT Technical Research Centre of Finland, Espoo, Finland(Swepub:oru)moc
(författare)
-
Lähdesmäki, HarriDepartment of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland
(författare)
-
Rasool, OmidTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland
(författare)
-
Rao, Kanury V.Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland
(författare)
-
Aittokallio, TeroInternational Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States
(författare)
-
Lahesmaa, RiittaTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States
(författare)
-
Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, FinlandTurku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Immunity: Cell Press32:6, s. 852-8621074-76131097-4180
Internetlänk
Hitta via bibliotek
-
Immunity
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Elo, Laura L.
-
Järvenpää, Henna
-
Tuomela, Soile
-
Raghav, Sunil
-
Ahlfors, Helena
-
Laurila, Kirsti
-
visa fler...
-
Gupta, Bhawna
-
Lund, Riikka J.
-
Tahvanainen, Joh ...
-
Hawkins, R. Davi ...
-
Oresic, Matej, 1 ...
-
Lähdesmäki, Harr ...
-
Rasool, Omid
-
Rao, Kanury V.
-
Aittokallio, Ter ...
-
Lahesmaa, Riitta
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Cellbiologi
- Artiklar i publikationen
-
Immunity
- Av lärosätet
-
Örebro universitet