Sökning: onr:"swepub:oai:DiVA.org:oru-63632" > Genome-wide profili...
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000 | 05579naa a2200493 4500 | |
001 | oai:DiVA.org:oru-63632 | |
003 | SwePub | |
008 | 171222s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-636322 URI |
024 | 7 | a https://doi.org/10.1016/j.immuni.2010.06.0112 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Elo, Laura L.u Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut |
245 | 1 0 | a Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming |
264 | 1 | b Cell Press,c 2010 |
338 | a print2 rdacarrier | |
500 | a Funding agencies:European Commission EC-FP7-SYBILLA-201106 EC-FP7-NANOMMUNE-214281 EC-FP7-DIABIMMUNE-202063 CIMO/SitraSigrid Juselius FoundationDepartment of Biotechnology, Government of IndiaTurku University HospitalNote: The Turku Centre for Biotechnology is a joint department of the Turku University and the Åbo Akademi University | |
520 | a Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses. | |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
700 | 1 | a Järvenpää, Hennau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland4 aut |
700 | 1 | a Tuomela, Soileu Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland4 aut |
700 | 1 | a Raghav, Sunilu Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut |
700 | 1 | a Ahlfors, Helenau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; The National Graduate School in Informational and Structural Biology, Åbo Akademi University, Turku, Finland4 aut |
700 | 1 | a Laurila, Kirstiu Department of Signal Processing, Tampere University of Technology, Tampere, Finland4 aut |
700 | 1 | a Gupta, Bhawnau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut |
700 | 1 | a Lund, Riikka J.u Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Department of Biological Science, University of Sheffield, Sheffield, United Kingdom4 aut |
700 | 1 | a Tahvanainen, Johannau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Drug Discovery Graduate School, University of Turku, Turku, Finland4 aut |
700 | 1 | a Hawkins, R. Davidu Ludwig Institute for Cancer Research, University of California, San Diego CA, United States4 aut |
700 | 1 | a Oresic, Matej,d 1967-u VTT Technical Research Centre of Finland, Espoo, Finland4 aut0 (Swepub:oru)moc |
700 | 1 | a Lähdesmäki, Harriu Department of Signal Processing, Tampere University of Technology, Tampere, Finland; Department of Information and Computer Science, Helsinki University of Technology, Helsinki, Finland4 aut |
700 | 1 | a Rasool, Omidu Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland4 aut |
700 | 1 | a Rao, Kanury V.u Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland4 aut |
700 | 1 | a Aittokallio, Terou International Centre for Genetic Engineering and Biotechnology, New Delhi, India; Immune Disease Institute, Harvard Medical School, Boston MA, United States4 aut |
700 | 1 | a Lahesmaa, Riittau Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Immune Disease Institute, Harvard Medical School, Boston MA, United States4 aut |
710 | 2 | a Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finlandb Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland4 org |
773 | 0 | t Immunityd : Cell Pressg 32:6, s. 852-862q 32:6<852-862x 1074-7613x 1097-4180 |
856 | 4 | u https://doi.org/10.1016/j.immuni.2010.06.011y Fulltext |
856 | 4 | u http://www.cell.com/article/S1074761310002141/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-63632 |
856 | 4 8 | u https://doi.org/10.1016/j.immuni.2010.06.011 |
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