Sökning: onr:"swepub:oai:DiVA.org:oru-63677" >
Genomic, transcript...
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol
-
- Laurila, Pirkka-Pekka (författare)
- Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, Helsinki, Finland
-
- Surakka, Ida (författare)
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
-
- Sarin, Antti-Pekka (författare)
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
-
visa fler...
-
- Yetukuri, Laxman (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
-
- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland
-
- Söderlund, Sanni (författare)
- Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
-
- Naukkarinen, Jussi (författare)
- Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
-
- Tang, Jing (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland
-
- Kettunen, Johannes (författare)
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
-
- Mirel, Daniel B (författare)
- Program in Medical and Population Genetics, Broad Institute, Cambridge MA, United States
-
- Soronen, Jarkko (författare)
- Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
-
- Lehtimäki, Terho (författare)
- Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland
-
- Ruokonen, Aimo (författare)
- Institute of Diagnostics, University of Oulu, Oulu, Finland
-
- Ehnholm, Christian (författare)
- Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
-
- Eriksson, Johan G. (författare)
- Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland; Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland; Folkhälsan Research Centre, Helsinki, Finland; Vasa Central Hospital, Vasa, FinlandM; Department of Health Promotion and Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
-
- Salomaa, Veikko (författare)
- Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
-
- Jula, Antti (författare)
- Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
-
- Raitakari, Olli T (författare)
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Clinical Physiology, University of Turku, Turku University Hospital, Turku, Finland
-
- Järvelin, Marjo-Riitta (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Institute of Health Sciences, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland
-
- Palotie, Aarno (författare)
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland; Department of Medical Genetics, University of Helsinki, Helsinki, Finland; Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom; Program in Medical and Population Genetics, Broad Institute, Cambridge MA, United States
-
Peltonen, Leena (författare)
-
- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland
-
- Jauhiainen, Matti (författare)
- Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
-
- Taskinen, Marja-Riitta (författare)
- Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
-
- Ripatti, Samuli (författare)
- Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland; Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland; Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
-
visa färre...
-
(creator_code:org_t)
- Lippincott Williams & Wilkins, 2013
- 2013
- Engelska.
-
Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology. - : Lippincott Williams & Wilkins. - 1079-5642 .- 1524-4636. ; 33:4, s. 847-857
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVE: Low high-density lipoprotein cholesterol (HDL-C) is associated with cardiometabolic pathologies. In this study, we investigate the biological pathways and individual genes behind low HDL-C by integrating results from 3 high-throughput data sources: adipose tissue transcriptomics, HDL lipidomics, and dense marker genotypes from Finnish individuals with low or high HDL-C (n=450).APPROACH AND RESULTS: In the pathway analysis of genetic data, we demonstrate that genetic variants within inflammatory pathways were enriched among low HDL-C associated single-nucleotide polymorphisms, and the expression of these pathways upregulated in the adipose tissue of low HDL-C subjects. The lipidomic analysis highlighted the change in HDL particle quality toward putatively more inflammatory and less vasoprotective state in subjects with low HDL-C, as evidenced by their decreased antioxidative plasmalogen contents. We show that the focal point of these inflammatory pathways seems to be the HLA region with its low HDL-associated alleles also associating with more abundant local transcript levels in adipose tissue, increased plasma vascular cell adhesion molecule 1 (VCAM1) levels, and decreased HDL particle plasmalogen contents, markers of adipose tissue inflammation, vascular inflammation, and HDL antioxidative potential, respectively. In a population-based look-up of the inflammatory pathway single-nucleotide polymorphisms in a large Finnish cohorts (n=11 211), no association of the HLA region was detected for HDL-C as quantitative trait, but with extreme HDL-C phenotypes, implying the presence of low or high HDL genes in addition to the population-genomewide association studies-identified HDL genes.CONCLUSIONS: Our study highlights the role of inflammation with a genetic component in subjects with low HDL-C and identifies novel cis-expression quantitative trait loci (cis-eQTL) variants in HLA region to be associated with low HDL-C.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Laurila, Pirkka- ...
-
Surakka, Ida
-
Sarin, Antti-Pek ...
-
Yetukuri, Laxman
-
Hyötyläinen, Tuu ...
-
Söderlund, Sanni
-
visa fler...
-
Naukkarinen, Jus ...
-
Tang, Jing
-
Kettunen, Johann ...
-
Mirel, Daniel B
-
Soronen, Jarkko
-
Lehtimäki, Terho
-
Ruokonen, Aimo
-
Ehnholm, Christi ...
-
Eriksson, Johan ...
-
Salomaa, Veikko
-
Jula, Antti
-
Raitakari, Olli ...
-
Järvelin, Marjo- ...
-
Palotie, Aarno
-
Peltonen, Leena
-
Oresic, Matej, 1 ...
-
Jauhiainen, Matt ...
-
Taskinen, Marja- ...
-
Ripatti, Samuli
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Arteriosclerosis ...
- Av lärosätet
-
Örebro universitet