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Treatment of PANDAS...
Treatment of PANDAS and PANS : a systematic review
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- Sigra, Sofia, 1991- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Region Örebro County, Örebro, Sweden
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- Hesselmark, Eva, 1981- (författare)
- Karolinska Institutet
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- Bejerot, Susanne, 1955- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Region Örebro County, Örebro, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- Elsevier, 2018
- 2018
- Engelska.
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Ingår i: Neuroscience and Biobehavioral Reviews. - : Elsevier. - 0149-7634 .- 1873-7528. ; 86, s. 51-56
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are a subtype of acute-onset obsessive-compulsive disorder (OCD) thought to be caused by an autoimmune response to group A streptococcal infection. Based on this proposed pathophysiology, alternative treatments for acute-onset OCD have been introduced, including antibiotics and immunomodulatory interventions. However, the literature on treatment of PANDAS is diverse, and clinical consensus regarding optimal treatment strategy is lacking. We conducted a systematic review of articles in PubMed, Cochrane Library, and Scopus that addressed treatment for PANDAS and related disorders. Twelve research studies involving the following treatments met inclusion criteria: penicillin, azithromycin, intravenous immunoglobulin, plasma exchange, tonsillectomy, cognitive behavior therapy, NSAID and corticosteroids. In addition, 65 case reports in which patients received immunomodulatory treatments, antibiotics, and/or psychotropics were identified. We determined that rigorously conducted research regarding treatments for PANDAS is scarce, and published studies have a high risk of bias. Further research is needed in which promising treatment strategies for PANDAS and other variants of OCD with proposed autoimmune etiology are rigorously investigated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections; PANDAS; Pediatric acute-onset neuropsychiatric syndrome; PANS; PITAND; Childhood acute neuropsychiatric symptoms; CANS; Obsessive-compulsive disorder; OCD; Obsessive-compulsive symptoms; Treatment; Therapy; Systematic review
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